2010 MERCEDES-BENZ E350 Front

If no damage on major assemblies, fuel
system, and engine mount can be
determined:
XStart the engine in the usual manner.
Parking
GWarning!
Do not park this vehicle in areas where
combustible materials such as grass, hay or
leaves can come into contact with the hot
exhaust system. These materials could be
ignited and cause a vehicle fire.
Vehicle movement may result in serious
personal injury or damage to the vehicle or
vehicle drivetrain. Therefore, always do the
following before turning off the engine and
leaving the vehicle:
RKeep right foot on the brake pedal.
REngage the parking brake.
RShift the automatic transmission into park
position P.
RSlowly release the brake pedal.
RWhen parked on an incline, always turn the
front wheels towards the road curb.
RTurn the SmartKey in the starter switch to
position 0 and remove the SmartKey from
the starter switch, or press the KEYLESS-
GO start/stop button.
RTake the SmartKey with you and lock the
vehicle when leaving.
Parking brake
GWarning!
Engaging the parking brake while the vehicle
is in motion can cause the rear wheels to lock
up. You could lose control of the vehicle and
cause an accident. In addition, the vehicle’s
brake lights do not light up when the parking
brake is engaged.
GWarning!
When leaving the vehicle, always remove the
SmartKey from the starter switch, take it with
you, and lock the vehicle. Do not leave
children unattended in the vehicle, or with
access to an unlocked vehicle. Children could
release the parking brake and/or shift the
automatic transmission out of park position
P, either of which could result in an accident
and/or serious personal injury.
XReleasing: Pull on release handle :.
When the ignition is switched on or the
engine is running, the brake warning lamp
$ (USA only) or J (Canada only) in
the instrument cluster goes out.
XEngaging: Step on parking brake
pedal ; firmly.
When the engine is running, the brake
warning lamp $ (USA only) or J
(Canada only) in the instrument cluster
comes on.
Turning off the engine
GWarning!
Do not turn off the engine before the vehicle
has come to a complete stop. With the engine
not running, there is no power assistance for
the brake and steering systems. In this case,
it is important to keep in mind that a
considerably higher degree of effort is
necessary to brake and steer the vehicle.
Driving and parking113Controls in detail212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 113Z

XShift the automatic transmission into park
position P (Y page 116).XEngage the parking brake.
i
Always engage the parking brake in
addition to shifting the automatic
transmission into park position P.
i Observe instructions if you want the
automatic transmission to remain in
neutral position N, see “Remaining in
neutral position N” ( Y page 115).
With SmartKey
XTurn the SmartKey in the starter switch to
position 0.XRemove the SmartKey from the starter
switch.
When you turn off the engine using the
SmartKey, and remove the SmartKey from
the starter switch or open a front door, the
automatic transmission will shift into park
position P automatically.
GWarning!
Keep in mind that turning off the engine alone
only will shift the automatic transmission into
neutral position N automatically.
Always shift the automatic transmission into
park position P before turning off the engine.
Otherwise the vehicle could roll away which
could result in an accident and/or serious
personal injury.
With KEYLESS-GO
XPress the KEYLESS-GO start/stop button.
With the driver’s door closed, the starter
switch is now in position 1. With the driver’s
door opened, the starter switch is set to
position 0, same as the SmartKey removed
from the starter switch ( Y page 85).
When you turn off the engine using the
KEYLESS-GO start/stop button and open a
front door, the automatic transmission will
shift into park position P automatically.
GWarning!
Keep in mind that turning off the engine alone
only will shift the automatic transmission into
neutral position N automatically.
Always shift the automatic transmission into
park position P before turning off the engine.
Otherwise the vehicle could roll away which
could result in an accident and/or serious
personal injury.
i In an emergency you can turn off the
engine while driving by pressing and
holding the KEYLESS-GO start/stop button
for approximately 3 seconds.
If you have started the engine with the
KEYLESS-GO start/stop button and cannot
turn it off as described above:
XRemove the KEYLESS-GO start/stop
button from the starter switch.XInsert the SmartKey into the starter switch.
The engine turns off. The starter switch is
in position 0 (Y page 85).
Automatic transmission
Introduction
For information on driving with an automatic
transmission, see “Driving and parking”
( Y page 109).
GWarning!
Make sure absolutely no objects are
obstructing the pedals’ range of movement.
Keep the driver’s footwell clear of all
obstacles. If there are any floormats or
carpets in the footwell, make sure the pedals
still have sufficient clearance.
During sudden driving or braking maneuvers
the objects could get caught between or
under the pedals. You could then no longer
brake or accelerate. This could lead to
accidents and injury.
114Automatic transmissionControls in detail
212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 114

i Shifting the automatic transmission out
of park position P is only possible with the
brake pedal depressed.
Without the brake pedal depressed, the
gear selector lever can be moved up or
down, but the parking pawl remains
engaged, not allowing shifting to occur.
i The gear selector lever always returns to
its original position.
The current transmission position P, R, N,
or D appears in the multifunction display
(Y page 118).
E 63 AMG only: There are additional
indicators on the cover of the shifting gate
showing the current gear selector lever
position.
The indicators come on when you insert the
SmartKey into the starter switch, and go out
when you remove the SmartKey from the
starter switch.
GWarning!
Keep in mind that turning off the engine alone
only will shift the automatic transmission into
neutral position N automatically.
Always shift the automatic transmission into
park position P before turning off the engine.
Otherwise the vehicle could roll away which
could result in an accident and/or serious
personal injury.
iMoving the gear selector lever up or down
shifts the automatic transmission out of
park position P.
All models except E 63 AMG: Shifting
into park position P
XWith the vehicle at a standstill, press
button : on the gear selector lever.
SmartKey: When you turn off the engine using
the SmartKey, and remove the SmartKey
from the starter switch or open a front door,
the automatic transmission will shift into park
position P automatically.
KEYLESS-GO: When you turn off the engine
using the KEYLESS-GO start/stop button and
open a front door, the automatic transmission
will shift into park position P automatically.
GWarning!
Keep in mind that turning off the engine alone
only will shift the automatic transmission into
neutral position N automatically.
Always shift the automatic transmission into
park position P before turning off the engine.
Otherwise the vehicle could roll away which
could result in an accident and/or serious
personal injury.
iMoving the gear selector lever up or down
shifts the automatic transmission out of
park position P.
HOLD function or DISTRONIC PLUS:
The automatic transmission will shift into
park position P automatically when HOLD
function or DISTRONIC PLUS brings your
vehicle to standstill. In addition, at least one
of the following conditions must be met:
RThe engine is turned off.
RThe driver’s door is opened and the seat
belt is not inserted in the seat belt buckle.
E 63 AMG: Shifting into park position P
XWith the vehicle at a standstill, press
button : on the gearshift pattern.
116Automatic transmissionControls in detail
212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 116

GWarning!
Keep in mind that turning off the engine alone
only will shift the automatic transmission into
neutral position N automatically.
Always shift the automatic transmission into
park position P before turning off the engine.
Otherwise the vehicle could roll away which
could result in an accident and/or serious
personal injury.
Shifting into neutral position N
XWith the vehicle at a standstill, depress the
brake pedal.XMove the gear selector lever up or down to
the resistance point to select neutral
position N.
When you turn off the engine, the automatic
transmission will shift into neutral position
N automatically.
SmartKey: Removing the SmartKey from the
starter switch or opening a front door after
turning off the engine will shift the automatic
transmission into park position P
automatically.
KEYLESS-GO: Opening a front door after
turning off the engine will shift the automatic
transmission into park position P
automatically.
Remaining in neutral position N
If you want the automatic transmission to
remain in neutral position N, e.g. when taking
the vehicle through an automatic conveyor-
type car wash, observe the following
instructions.
GWarning!
When leaving the SmartKey in the starter
switch, do not leave children unattended in
the vehicle. It is possible for children to switch
on the ignition which could result in
unsupervised use of vehicle equipment.
Unsupervised use of vehicle equipment could
result in an accident and/or serious personal
injury.
With SmartKey:XMake sure the ignition is switched on.XWith the vehicle at a standstill, depress the
brake pedal and keep it pressed.XShift the automatic transmission into
neutral position N.XRelease the brake pedal.XIf engaged, release the parking brake.XSwitch off the ignition and leave the
SmartKey in the starter switch.
With KEYLESS-GO:
XMake sure the ignition is switched on.XWith the vehicle at a standstill, depress the
brake pedal and keep it pressed.XShift the automatic transmission into park
position P.XRelease the brake pedal.XRemove the KEYLESS-GO start/stop
button from the starter switch.XInsert the SmartKey into the starter switch.XSwitch on the ignition.XDepress the brake pedal and keep it
pressed.XShift the automatic transmission into
neutral position N.XRelease the brake pedal.XIf engaged, release the parking brake.XSwitch off the ignition and leave the
SmartKey in the starter switch.
Shifting into reverse gear R
XWith the vehicle at a standstill, depress the
brake pedal.XMove the gear selector lever up past the
resistance point.
Shifting into drive position D
XWith the vehicle at a standstill, depress the
brake pedal.XMove the gear selector lever down past the
resistance point.Automatic transmission117Controls in detail212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 117Z

DownshiftingGWarning!
On slippery road surfaces, never downshift in
order to obtain braking action. This could
result in drive wheel slip and reduced vehicle
control. Your vehicle’s ABS will not prevent
this type of loss of control.
XBriefly pull left gearshift control :
( Y page 122).
The automatic transmission shifts into the
next lower gear.
i When you brake or stop, the automatic
transmission shifts down into a gear from
which you can easily accelerate or take off.
Kickdown
Using the kickdown while driving in manual
program mode M is not possible.
Deactivating manual shift program
XTurn the program mode selector dial until
C or S appears in the multifunction display.
or
XRestart the engine.
The automatic transmission will go to
automatic program mode C.
Manual program mode M is not stored.
Emergency operation (limp-home
mode)
If vehicle acceleration becomes less
responsive or sluggish or the automatic
transmission no longer shifts, the automatic
transmission is most likely operating in limp-
home (emergency operation) mode. In this
mode only second gear and reverse gear R
can be selected.
XStop the vehicle in a safe location.XShift the automatic transmission into park
position P.XTurn off the engine.XWait at least 10 seconds before restarting.XRestart the engine.XShift the automatic transmission into drive
position D (for second gear) or reverse gear
R .XHave the automatic transmission checked
at an authorized Mercedes-Benz Center as
soon as possible.
Transfer case
This section applies to vehicles equipped with
all-wheel drive (4MATIC) only. Both the front
and rear axles are powered at all times when
the vehicle is being operated.
! Only conduct operational or performance
tests on a two-axle dynamometer. If such
tests are necessary, contact an authorized
Mercedes-Benz Center. You could
otherwise seriously damage the brake
system or the transfer case which is not
covered by the Mercedes-Benz Limited
Warranty.
! Because the ESC operates automatically,
the engine and ignition must be shut off
(SmartKey in starter switch position 0, or
1 , or KEYLESS-GO start/stop button in
position 0, or 1) when
R the parking brake is being tested on a
brake test dynamometer
R towing the vehicle with the front or rear
axle raised (not permissible for vehicles
with 4MATIC)
Active braking action through the ESC may
otherwise seriously damage the brake
system which is not covered by the
Mercedes-Benz Limited Warranty.
124Transfer caseControls in detail
212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 124

If, after turning off the engine, you do not
open or close a door, the lamps will
automatically go out after 60 seconds.
The following lamps will come on
RParking lamps
RTail lamps
RLicense plate lamps
RSide marker lamps
RFront fog lamps
XPress button = or ; to select the
Sett. menu.
XPress button : or 9 to select the
Lights submenu.
XPress button a.XPress button : or 9 to select the
Locator Lighting: function.
The current setting Enabled or Disabled
is shown.
XPress button a to change the current
status.
Depending on the previous status, the
Locator Lighting: function will be
Enabled or Disabled.
You can temporarily deactivate the
headlamps delayed shut-off feature:
XBefore exiting the vehicle, turn the
SmartKey in the starter switch to
position 0.
XThen turn it to position 2 and back to
position 0.
The headlamps delayed shut-off feature is
deactivated. It will reactivate as soon as
you start the engine.
Setting ambient lighting
Use this function to adjust the brightness of
the ambient lighting.
XPress button = or ; to select the
Sett. menu.
XPress button : or 9 to select the
Lights submenu.
XPress button a.XPress button : or 9 to select the
Ambient Light Brightness: function.
XPress button a.XPress button : or 9 to set the
Ambient Light Brightness: .
The setting Level 1 represents the darkest
level and setting Level 5 the brightest
level. The ambient light is switched off at
setting Disabled.
Switching interior lighting delayed shut-
off on or off
Use this function to set whether you would
like the interior lighting to remain on for
10 seconds during darkness after you have
removed the SmartKey from the starter
switch.
XPress button = or ; to select the
Sett. menu.
XPress button : or 9 to select the
Lights submenu.
XPress button a.XPress button : or 9 to select the
Interior Lighting Delay: function.
The current setting Enabled or Disabled
is shown.
Control system143Controls in detail212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 143Z

Removal, tampering, or altering of the
device will void any warranties, and is not
permitted. Do not tamper with, alter, or use
in any non-approved way.
Any unauthorized modification to this
device could void the user’s authority to
operate the equipment.
XPress button = or ; to select the
Sett. menu.
XPress button : or 9 to select the
Vehicle submenu.
XPress button a.XPress button : or 9 to select the
Radar Sensor (See Oper. Manual):
function.
The current setting Enabled or Disabled
is shown.
XPress button a again if you would like
to change the current status.
Depending on the previous status, the
radar sensors will be switched on
(Enabled) or off (Disabled).
iThe selected status of the radar sensors
remains stored in memory even if the
engine is turned off and restarted.
Convenience submenu
Access the Convenience submenu via the
Sett. menu. Use the Convenience submenu
to activate the easy-entry/exit feature
(Y page 145) or to activate the seat belt
adjustment feature (Y page 145).
Activating easy-entry/exit feature
Use this function to activate and deactivate
the easy-entry/exit feature (Y page 93).
GWarning!
You must make sure no one can become
trapped or injured by the moving steering
wheel when the easy-entry/exit feature is
activated.
To stop steering wheel movement, move
steering wheel adjustment stalk or press one
of the memory position buttons.
Do not leave children unattended in the
vehicle, or with access to an unlocked vehicle.
Children could open the driver’s door and
unintentionally activate the easy-entry/exit
feature, which could result in an accident
and/or serious personal injury.
XPress button = or ; to select the
Sett. menu.
XPress button : or 9 to select the
Convenience submenu.
XPress button a.XPress button : or 9 to select the
Easy Entry/Exit: function.
The current setting Enabled or Disabled
is shown.
XPress button a to change the current
status.
Depending on the previous status, the
Easy Entry/Exit: feature will be
Enabled or Disabled.
Activating/deactivating seat belt
adjustment function
Use this function to set the seat belts to be
adjusted automatically with the driver’s or
front passenger seat belt fastened and the
starter switch in position 2.
For more information on the seat belt
adjustment function, see (Y page 51).
Control system145Controls in detail212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 145Z

XBriefly pull the cruise control lever in
direction of arrow ?.
If no speed is stored, the current speed is
set and stored.XRemove your foot from the accelerator
pedal.
The last stored speed is deleted from memory
when the engine is turned off.
DISTRONIC PLUS
Safety notes
When activated, the DISTRONIC PLUS
adaptive cruise control system increases the
driving convenience afforded by the cruise
control while traveling on expressways and
other major roadways.
R If the DISTRONIC PLUS distance sensor
detects a slower moving vehicle directly
ahead, your vehicle speed will be reduced
so that you follow that vehicle at your
preset following distance.
R If there is no vehicle directly ahead of you,
the DISTRONIC PLUS will function in the
same way as standard cruise control
( Y page 146).
GWarning!
The DISTRONIC PLUS requires familiarity with
its operational characteristics. We strongly
recommend that you review the following
information carefully before operating the
system.
GWarning!
The DISTRONIC PLUS is a convenience
system. Its speed adjustment reduction
capability is intended to make cruise control
more effective and usable when traffic speeds
vary. It is not however, intended to, nor does
it, replace the need for extreme care.
The responsibility for the vehicle’s speed,
distance to the preceding vehicle and, most
importantly, brake operation to ensure a safe
stopping distance, always remains with the
driver.
The DISTRONIC PLUS cannot take street and
traffic conditions into account.
Complex driving situations are not always
fully recognized by the DISTRONIC PLUS. This
could result in wrong or missing distance
warnings.GWarning!
The DISTRONIC PLUS adaptive cruise control
is not a substitute for active driving
involvement. It does not react to pedestrians
or on stationary objects, nor does it recognize
or predict the curvature and lane layout or the
movement of preceding vehicles. The
DISTRONIC PLUS can only apply a maximum
of 40% of the vehicle’s braking power.
The DISTRONIC PLUS may not detect narrow
vehicles possibly driving in front of you, such
as motorcycles and vehicles driving in an
offset formation.
It is the driver’s responsibility at all times to
be attentive to the road, weather and traffic
conditions. Additionally, the driver must
provide the steering, braking and other driving
inputs necessary to remain in control of the
vehicle.
High-frequency sources such as toll stations,
speed measuring systems etc. can cause the
DISTRONIC PLUS system to temporarily
cease functioning.
GWarning!
The DISTRONIC PLUS cannot take road and
traffic conditions into account. Only use the
DISTRONIC PLUS if the road, weather and
traffic conditions make it advisable to travel
at a constant speed.
GWarning!
Use of the DISTRONIC PLUS can be
dangerous on slippery roads. Rapid changes
in tire traction can result in wheel spin and
loss of control.
Driving systems149Controls in detail212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 149Z