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1Steering wheel gearshift paddle →
18
2 Combination switch
3 DIRECT SELECT le ver
4 Displ ay(multimedia sy stem)
5 Start/ Stop button
6 Control panel forth e multimedia sy stem
7 Climate control sy stems
8 Glovebox
9 Hazard warning lights
A Stow age compartment
B Controls forth e multimedia sy stem
C AMG Performance exhaust sy stem (Mercedes-
AMG E 63 4MATIC and E63 S 4MATIC only) →
14
D ECO start/ stop function
E Parking Pilot
F Toactivate/deactivate ESP
®→
21
To activate/deactivate SPO RThandling mode →
21
GAMG RIDE CONTROL (suspension tuning) →
25
H Manual gearshifting (permanent setting) →
18
I DYNA MIC SELECT switch
J PASSENGER AIRB AGindicator lamps
K Cont rol panel forth e multimedia sy stem
L Toadjust thesteering wheel
M Control panel forth e on-board computer
N Cruise control le ver
O Tounlo ckthe hood
P Elect ric park ing brake
Q Light switch
R Cont rol panel for:
St eering Pilot
Ac tive Lane Keeping Assist
Pa rking Assist PARKTRONI C
Head-up Displa y
Ataglance – Cockpit 9
Page 12 of 50
Rear wind ow roller sunblindSetting theve hicle le vel
10
Ataglance – Cockpit
Page 13 of 50
Reduced pr otection
The AMG sport seat and the AMG Performance
seat are designed forth est andard thre e-point
seat belt. If you ins tall ano ther multipoint seat
belt, e.g. sport or racing seat belts, there stra int
sy stem may not pr ovide the cor rect le vel of pro‐
te ction.
Depending on the type of seat, there may be
openings in the seat backrest. These openings
ha ve no function.
&
WARNING Risk of injury orfata l injury
due tomodified seat belt sy stems
If yo ufe ed seat belts thro ugh the opening in
th e seat backrest, the seat backrest may be
damaged or may even break in theeve nt of
an accident.
#Only use thest andard thre e-point seat
belt.
#Ne ver modify the seat belt sy stem.
Seat belts 11
Page 14 of 50
Adjusting the AMG per form ance seat
You can adjust the front seats individually to
adjust the conto ur ofthe seat and toimpr ove
lateral support.
#Side bols ter on the seat cushion: press
button 1or2 tonar row or widen.
#Seat side bols ter on the seat backres t:
press button 3or4 tonar row or widen.
12
Seats
Page 15 of 50

Notes on breaking-in a new vehicle
To preser vethe engine during thefirs t
1, 000 miles (1,500 km):
RDrive at varying road speeds and engine
speeds.
RDo not drive fasterthan 85 mph (140 km/h).
ROnly brief lyallow the engine toreach a maxi‐
mum engine speed of 4,500 rpm
(4,500 1/min) only brief ly.
RMercedes-AMG E 43 4MATIC: Drive in drive
program Cor E.
RMercedes‑AMG E 63 4MATIC and
Mercedes‑AMG E 63 S 4MATIC: Drive in
drive program C.
RChange up before theta ch ome ter needle is
Ô ofthewa yto there d area of theta ch ome‐
te r.
RDo not shi ftdown a gear manually in order to
brake.
RAv oid overstra ining theve hicle, e.g. driving at
full thro ttle.
RDo not depress the accelera tor pedal be yond
th e pressure point (kickdown).
ROnly increase the engine speed gradually and
accelera tetheve hicle tofull speed af ter
1, 000 miles (1,500 km).
This also applies when the engine or parts of the
driv etra in ha vebeen replaced.
Please also obser vethefo llowing running-in
no tes:
RIn cer tain driving and driving saf etysy stems,
th e sensors adjust automatically while a cer‐
ta in dis tance is being driven af terth eve hicle
has been delivered or af terre pairs.
Full sys‐
te m ef fecti
veness is not achie ved until the
end of this teach-in process.
RBrake linings, brake discs and tires that are
either new or ha vebeen replaced only ach‐
ie ve optimum braking ef fect and grip af ter
se veral hundred kilom eters of driving. Com‐
pensate forth ere duced braking ef fect by
applying greaterfo rc eto the brake pedal.
Note s onthere ar axle locking dif fere ntial
The rear axle locking dif fere ntial is only
av ailable for the
Merc edes‑AMG E 63 4MATIC and
Mercedes‑AMG E 63 S 4MATIC models.
Changing the oil at there ar axle prolongs the
service life of the dif fere ntial.
Ha ve the oil change car ried out at a qualified
specialist workshop:
RAf ter a breaking-in period of 2000 miles
(3000 km).
REvery 30000 miles (50000 km) or thre e
ye ars.
Operation of the ECO start/s top function
The engine is switched off au tomatical ly:
RIf yo u brake theve hicle toast andstill in
transmission position hori.
RIf all vehicle conditions for an au tomatic
engine stop are met.
The è symbol appears in the multifunction
display when theve hicle is stationar y.
Driving 13
Page 16 of 50

The engine isrestar ted automatically if:
RYo ure lease the brake pedal with the trans‐
mission in position hwhen the HOLD func‐
tion is not active.
RYo u shift from transmission position j.
RYou enga getransmission position hork.
RYoudepr essthe accelerator pedal.
RMercedes-AMG E 43 4MATIC: Youswit chto
drive program S+.
RMercedes-AMG E 63 4MATIC: Youswit chto
drive prog ram Sor S+.
RMercedes-AMG E 63 S 4MATIC: Youswit ch
to drive prog ram S, S+ orRACE .
RYou permanently act ivate manual gearshift‐
ing.
RYo upull the left-hand steering wheel gear‐
shift paddle.
RYo uch ange theve hicle le vel.
RAn automatic engine start is necessar y.
If th e engine was switched off bythe ECO start/
st op function and you lea vetheve hicle, a warn‐ ing
tone sounds. The Vehicle Operational Switch
the Ignition Off Before Exiting displaymessage
also appears in the multifunction displa y.
If yo udo not swit choff the ignition, the ignition
is automatically switched off af ter one minute.
AMG Performance exhaust sy stem
Fu nction of the AMG Performance exhaust
sy stem
The AMG Performance exhaust sy stem is
only available for the
Merc edes‑AMG E 63 4MATIC and
Mercedes‑AMG E 63 S 4MATIC models.
Changing the position of theex haust gasflap
allo wsyouto select thevo lume of the AMG Per‐
fo rm ance exhaust sy stem.
Operating the AMG Performance exhaust
sy stem
#Press button 1.
If indicator lamp 2lights up, the loudest
setting is selected.
14 Driving