
TABLE OF CONTENTS
2
RX350_U_OM48E90U For your information ................................... 8
Reading this manual................................... 12
How to search ..............................................13
Pictorial index ............................................... 14
1-1. For safe use
Before driving................................. 26
For safety drive............................... 28
Seat belts .......................................... 30
SRS airbags ..................................... 36
Front passenger occupant
classification system.................. 49
Exhaust gas precautions ............ 55
1-2. Child safety
Riding with children ..................... 56
Child restraint systems ................57
1-3. Theft deterrent system
Engine immobilizer system........ 74
Alarm .................................................. 76
Theft prevention labels ............... 78
2. Instrument cluster
Warning lights and
indicators.......................................80
Gauges and meters ..................... 85
Multi-information display .......... 89
Head-up display ...........................107
Fuel consumption
information ................................... 113 3-1. Key information
Keys ...................................................120
3-2. Opening, closing and
locking the doors
Side doors....................................... 124
Power back door......................... 130
Smart access system
with push-button start .............146
3-3. Adjusting the seats
Front seats....................................... 152
Rear seats........................................153
Driving position memory.......... 162
Head restraints ............................. 167
3-4. Adjusting the steering
wheel and mirrors
Steering wheel ..............................169
Inside rear view mirror ............... 171
Outside rear view mirrors........ 173
3-5. Opening, closing
the windows and
moon roof
Power windows............................. 177
Moon roof ........................................ 181
Panoramic moon roof ............... 1851
For safety and security
2
Instrument cluster 3
Operation of each
component

11
RX350_U_OM48E90U The SRS airbag and seat belt pretensioner devices in your Lexus contain explosive
chemicals. If the vehicle is scrapped with the airbags and seat belt pretensioners left as
they are, this may cause an accident such as fire. Be sure to have the systems of the SRS
airbag and seat belt pretensioner removed an d disposed of by a qualified service shop or
by your Lexus dealer before you scrap your vehicle.
Special handling may apply, See www.dts c.ca.gov/hazardouswaste/perchlorate.
Your vehicle has components that may contain perchlorate. These components may
include airbag, seat belt pretensioners, and wireless remote control batteries.Scrapping of your Lexus
Perchlorate Material WA R N I N G ■
General precautions while driving
Driving under the influence: Never drive your vehicle when under the influence of
alcohol or drugs that have im paired your ability to operate your vehicle. Alcohol and
certain drugs delay reaction time, impair judgment and reduce coordination, which
could lead to an accident that could result in death or serious injury.
Defensive driving: Always drive defensively. Anticipate mistakes that other drivers or
pedestrians might make and be ready to avoid accidents.
Driver distraction: Always give your full atte ntion to driving. Anything that distracts the
driver, such as adjusting controls, talking on a cellular phone or reading can result in a
collision with resulting death or serious in jury to you, your occupants or others.■
General precaution regarding children’s safety
Never leave children unattended in the vehicle, and never allow children to have or use
the key.
Children may be able to start the vehicle or sh ift the vehicle into neutral. There is also a
danger that children may injure themselves by playing with the windows, the moon roof
or panoramic moon roof, or other features of the vehicle. In addition, heat build-up or
extremely cold temperatures inside the vehicle can be fatal to children.

23Pictorial index
RX350_U_OM48E90U Auxiliary box. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .P. 517
Interior light
* 3
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 509
Pe r s o n a l l i g h t s
* 3
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 510
Moon roof switches
* 1
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 181
Panoramic moon roof switches
* 1
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 185
“SOS” button
* 1
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 547
Vanity mirrors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 523
Sun visors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 523
Inside rear view mirror . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 171
Garage door opener switches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 536
* 1
: If equipped
* 2
: Refer to “NAVIGATION SYSTEM OWNER’S MANUAL”.
* 3
: The illustration shows the front, but they are also equipped in the rear.1
2
3
4
5
6
7
8

411-1. For safe use
1
For safety and security
RX350_U_OM48E90U WA R N I N G ■
SRS airbag precautions ●
Do not sit on the edge of the seat or lean
against the dashboard. ●
Do not allow a child to stand in front of the
SRS front passenger airbag unit or sit on the
knees of a front passenger. ●
Do not allow the front seat occupants to hold
items on their knees. ●
Do not lean against the door, the roof side rail
or the front, side and rear pillars.
●
Do not allow anyone to kneel on the passen-
ger seats toward the door or put their head or
hands outside the vehicle.

42 1-1. For safe use
RX350_U_OM48E90U WA R N I N G ■
SRS airbag precautions
●
Do not hang coat hangers or other hard objects on the coat hooks. All of these items
could become projectiles and may cause deat h or serious injury, should the SRS cur-
tain shield ai rbags deploy.●
If a vinyl cover is put on the area where the SRS knee airbag will deploy, be sure to
remove it. ●
Do not use seat accessories which cover the parts where the SRS side airbags and
SRS seat cushion airbag inflate as they may interfere with inflation of the SRS airbags.
Such accessories may prevent the side ai rbags and SRS seat cushion airbag from
activating correctly, disable the system or cause the side airbag s and SRS seat cush-
ion airbag to inflate accidentally, re sulting in death or serious injury.●
Do not strike or apply significant levels of force to the areas around the SRS airbag
components or the front doors.
Doing so can cause the SRS airbags to malfunction. ●
Do not touch any of the component parts immediately after the SRS airbags have
deployed (inflated) as they may be hot. ●
Do not attach anything to or lean anything
against areas such as the dashboard, steering
wheel pad and lower portion of the instru-
ment panel.
These items can become projectiles when the
SRS driver, front passenger and knee airbags
deploy. ●
Do not attach anything to areas such as a
door, windshield, side windows, front or rear
pillar, roof side rail and assist grip.

431-1. For safe use
1
For safety and security
RX350_U_OM48E90U WA R N I N G ■
SRS airbag precautions ●
If breathing becomes difficult after the SRS airbags have deployed, open a door or
window to allow fresh air in, or leave the vehicl e if it is safe to do so. Wash off any resi-
due as soon as possible to prevent skin irritation. ●
If the areas where the SRS airbags are stored, such as the steering wheel pad and
front and rear pillar garnishes, are damaged or cracked, have them replaced by your
Lexus dealer. ●
Do not place anything, such as a cushion, on the front passenger’s seat. Doing so will
disperse the passenger’s weight, which prevents the sensor from detecting the pas-
senger’s weight properly. As a result, th e SRS front airbags for the front passenger
may not deploy in the event of a collision. ■
Modification and disposal of SRS airbag system components
Do not dispose of your vehicle or perform any of the following modifications without
consulting your Lexus dealer. The SRS airb ags may malfunction or deploy (inflate)
accidentally, causing de ath or serious injury.●
Installation, removal, disassembl y and repair of the SRS airbags●
Repairs, modifications, removal or replac ement of the steering wheel, instrument
panel, dashboard, seats or seat upholstery, front, side and rear pillars, roof side rails,
front door panels, front door trims, or front door speakers ●
Modifications to the front door pa nel (such as making a hole in it)●
Repairs or modifications of the front fend er, front bumper, or side of the occupant
compartment ●
Installation of a grille guar d (bull bars, kangaroo bar, etc.), snow plows, winches or
roof luggage carrier ●
Modifications to the vehicle’s suspension system ●
Installation of electronic devices such as mobile two-way radios and CD players●
Modifications to your vehicle for a person with a physical disability

44 1-1. For safe use
RX350_U_OM48E90U ■
If the SRS airbags deploy (inflate) ●
Slight abrasions, burns, bruising etc., may be sustained from SRS airbags, due to the
extremely high speed deployment (inflation) by hot gases. ●
A loud noise and white powder will be emitted. ●
Parts of the airbag module (steering wheel hub, airbag cover and inflator) as well as the
front seats, parts of th e front and rear pillars, and roof side rails, may be hot for several
minutes. The airbag itself may also be hot. ●
The windshield may crack. ●
For Lexus Enform Safety Connect subscribers, if the SRS airb ags deploy or in the event
of a severe rear-end collision, the system is designed to send an emergency call to the
response center, notifying them of the vehicl e’s location (without needing to push the
“SOS” button) and an agent will attempt to speak with the occupants to ascertain the
level of emergency and assistance required . If the occupants are unable to communi-
cate, the agent automatically treats the call as an emergency and helps to dispatch the
necessary emergency services. ( P. 5 4 7 )■
SRS airbag deployment conditions (SRS front airbags) ●
The SRS front airbags will deploy in the event of an impact that exceeds the set threshold
level (the level of force corresponding to an approximately 12-18 mph [20-30 km/h]
frontal collision with a fixed wall that does not move or deform).
However, this threshold velocity will be considerably higher in the following situations:
• If the vehicle strikes an object, such as a parked vehicle or sign pole, which can move
or deform on impact
• If the vehicle is involved in an underride collision, such as a collision in which the
front of the vehicle “underrides”, or goes under, the bed of a truck●
Depending on the type of collision, it is possib le that only the seat belt pretensioners will
activate. ●
The SRS front airbags for the front passenger will not activate if there is no passenger
sitting in the front passenger seat. However, the SRS front airbags for the front passen-
ger may deploy if luggage is put in the seat, even if the se at is unoccupied. ( P. 4 9 )●
The SRS seat cushion airbag on the front passenger seat will not operate if the occu-
pant is not wearing a seat belt. ■
SRS airbag deployment conditions (S RS side and curtain shield airbags)●
The SRS side and curtain shield airbags wi ll deploy in the even t of an impact that
exceeds the set threshol d level (the level of force corresponding to the impact force
produced by an approximately 3300 lb. [1 500 kg] vehicle colliding with the vehicle
cabin from a direction perpendicular to the vehicle orientation at an approximate
speed of 12 -18 mph [20 -30 km/h]). ●
The SRS curtain shield airbags will deploy in the event of vehicle rollover. ●
The SRS side and curtain shield airbags will deploy in the event of a severe frontal colli-
sion.

48 1-1. For safe use
RX350_U_OM48E90U ●
The portion of the front pillars, rear pillars or
roof side rail garnishes (padding) containing
the curtain shield airbag s inside is scratched,
cracked, or otherwise damaged.