
TABLE OF CONTENTS
2
RX350_U_OM48E90U For your information ................................... 8
Reading this manual................................... 12
How to search ..............................................13
Pictorial index ............................................... 14
1-1. For safe use
Before driving................................. 26
For safety drive............................... 28
Seat belts .......................................... 30
SRS airbags ..................................... 36
Front passenger occupant
classification system.................. 49
Exhaust gas precautions ............ 55
1-2. Child safety
Riding with children ..................... 56
Child restraint systems ................57
1-3. Theft deterrent system
Engine immobilizer system........ 74
Alarm .................................................. 76
Theft prevention labels ............... 78
2. Instrument cluster
Warning lights and
indicators.......................................80
Gauges and meters ..................... 85
Multi-information display .......... 89
Head-up display ...........................107
Fuel consumption
information ................................... 113 3-1. Key information
Keys ...................................................120
3-2. Opening, closing and
locking the doors
Side doors....................................... 124
Power back door......................... 130
Smart access system
with push-button start .............146
3-3. Adjusting the seats
Front seats....................................... 152
Rear seats........................................153
Driving position memory.......... 162
Head restraints ............................. 167
3-4. Adjusting the steering
wheel and mirrors
Steering wheel ..............................169
Inside rear view mirror ............... 171
Outside rear view mirrors........ 173
3-5. Opening, closing
the windows and
moon roof
Power windows............................. 177
Moon roof ........................................ 181
Panoramic moon roof ............... 1851
For safety and security
2
Instrument cluster 3
Operation of each
component

TABLE OF CONTENTS
6
RX350_U_OM48E90U 7-1. Maintenance and care
Cleaning and protecting
the vehicle exterior ................ 556
Cleaning and protecting
the vehicle inte rior.................... 561
7-2. Maintenance
Maintenance
requirements ............................ 564
General maintenance.............. 566
Emission inspection and
maintenance (I/M)
programs .................................... 569
7-3. Do-it-yourself
maintenance
Do-it-yourself service
precautions................................ 570
Hood ................................................572
Positioning a floor jack..............573
Engine compartment ................ 574
Tires.................................................. 584
Tire inflation pressure ............... 593
Wheels ........................................... 596
Air conditioning filter ............... 598
Windshield wiper inserts ......... 601
Electronic key battery.............. 603
Checking and replacing
fuses.............................................. 605
Headlight aim ..............................608
Light bulbs ......................................610 8-1. Essential information
Emergency flashers ...................624
If your vehicle has to be
stopped in an
emergency ................................ 625
8-2. Steps to take in an
emergency
If your vehicle needs to
be towed ......................................626
If you think something is
wrong........................................... 632
Fuel pump shut off
system .......................................... 633
If a warning light turns
on or a warning buzzer
sounds ......................................... 634
If a warning message is
displayed ...................................... 641
If you have a flat tire .................. 646
If the engine will not start ........ 658
If the shift lever cannot be
shifted from P ........................... 660
If the electronic key does
not operate properly ............... 661
If the vehicle battery is
discharged ................................. 665
If your vehicle overheats ......... 668
If the vehicle becomes
stuck ............................................... 6717
Maintenance and care 8
When trouble arises

11
RX350_U_OM48E90U The SRS airbag and seat belt pretensioner devices in your Lexus contain explosive
chemicals. If the vehicle is scrapped with the airbags and seat belt pretensioners left as
they are, this may cause an accident such as fire. Be sure to have the systems of the SRS
airbag and seat belt pretensioner removed an d disposed of by a qualified service shop or
by your Lexus dealer before you scrap your vehicle.
Special handling may apply, See www.dts c.ca.gov/hazardouswaste/perchlorate.
Your vehicle has components that may contain perchlorate. These components may
include airbag, seat belt pretensioners, and wireless remote control batteries.Scrapping of your Lexus
Perchlorate Material WA R N I N G ■
General precautions while driving
Driving under the influence: Never drive your vehicle when under the influence of
alcohol or drugs that have im paired your ability to operate your vehicle. Alcohol and
certain drugs delay reaction time, impair judgment and reduce coordination, which
could lead to an accident that could result in death or serious injury.
Defensive driving: Always drive defensively. Anticipate mistakes that other drivers or
pedestrians might make and be ready to avoid accidents.
Driver distraction: Always give your full atte ntion to driving. Anything that distracts the
driver, such as adjusting controls, talking on a cellular phone or reading can result in a
collision with resulting death or serious in jury to you, your occupants or others.■
General precaution regarding children’s safety
Never leave children unattended in the vehicle, and never allow children to have or use
the key.
Children may be able to start the vehicle or sh ift the vehicle into neutral. There is also a
danger that children may injure themselves by playing with the windows, the moon roof
or panoramic moon roof, or other features of the vehicle. In addition, heat build-up or
extremely cold temperatures inside the vehicle can be fatal to children.

14
RX350_U_OM48E90U Pictorial index
Pictorial index ■ Exterior
The shape of the lights may differ depending on the grade, etc. ( P. 611)
Side doors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 124 Locking/unlocking . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 124
Opening/closing the side windows. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .P. 177
Locking/unlocking by using the mechanical key. . . . . . . . . . . . . . . . . . . . . . . . . P. 661
Back door . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 130Opening from inside the cabin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 131
Opening from outside . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 13 1
Outside rear view mirrors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 173 Adjusting the mirror angle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 173
Folding the mirrors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 173, 1 74
Driving position memory
* . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 162
Defogging the mirrors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . P. 500 *
1
2
3

56
RX350_U_OM48E90U 1-2. Child safety
●
It is recommended that children sit in the rear seats to avoid accidental con-
tact with the shift lever, wiper switch, etc. ●
Use the rear door child-protector lock or the window lock switch to avoid
children opening the door while driving or operating the power window acci-
dentally. ●
Do not let small children operate equi pment which may catch or pinch body
parts, such as the power window, hood, back door, seats etc.
Riding with children Observe the following precautions when children are in the vehicle.
Use a child restraint system appropriate for the child, until the child becomes
large enough to properly wear the vehicle’s seat belt.
WA R N I N G
Never leave children unattended in the vehicle, and never allow children to have or use
the key.
Children may be able to start the vehicle or sh ift the vehicle into neutral. There is also a
danger that children may injure themselves by playing with the windows, the moon roof
or panoramic moon roof, or other features of the vehicle. In addition, heat build-up or
extremely cold temperatures inside the vehicle can be fatal to children.

74
RX350_U_OM48E90U 1-3. Theft deterrent system
The indicator light flashes after the
engine switch has been turned off to
indicate that the system is operating.
The indicator light stops flashing after
the engine switch has been turned to
ACCESSORY or IGNITION ON
mode to indicate that the system has
been canceled. ■
System maintenance
The vehicle has a maintenance-free type engine immobilizer system. ■
Conditions that may cause the system to malfunction ●
If the grip portion of the key is in contact with a metallic object●
If the key is in close proximity to or touching a key registered to the security system (key
with a built-in transponder chip) of another vehicleEngine immobilizer system The vehicle’s keys have built-in transponder chips that prevent the engine
from starting if a key has not been prev iously registered in the vehicle’s on-
board computer.
Never leave the keys inside the vehicle when you leave the vehicle.
This system is designed to help prev ent vehicle theft but does not guarantee
absolute security against all vehicle thefts.

76 1-3. Theft deterrent system
RX350_U_OM48E90U The alarm uses light and sound to give an alert when an intrusion is detected.
The alarm is triggered in the following situations when the alarm is set: ●
A locked door is unlocked or opened in any way other than using the entry
function, wireless remote control or mech anical key. (The doors will lock again
automatically.) ●
The hood is opened.
Close the doors and hood, and lock all
the doors. The system will be set auto-
matically after 30 seconds. The indicator light changes from being
on to flashing when the system is set.
Do one of the following to de activate or stop the alarms:●
Unlock the doors. ●
Turn the engine switch to ACCESSORY or IGNITION ON mode, or start
the engine. (The alarm will be deactivat ed or stopped after a few seconds.)■
System maintenance
The vehicle has a maintenance-free type alarm system. ■
Items to check before locking the vehicle
To prevent unexpected triggering of the alarm and vehicle theft, make sure of the follow-
ing: ●
Nobody is in the vehicle. ●
The windows and moon roof or panoramic moon roof are closed before the alarm is
set. ●
No valuables or other personal items are left in the vehicle.Alarm The alarm
Setting the alarm system
Deactivating or stopping the alarm

119
3 Operation of
each component
RX350_U_OM48E90U 3-1. Key information
Keys .................................................. 120
3-2. Opening, closing and
locking the doors
Side doors ....................................... 124
Power back door ......................... 130
Smart access system with
push-button start...................... 146
3-3. Adjusting the seats
Front seats .......................................152
Rear seats ....................................... 153
Driving position memory ..........162
Head restraints ............................. 167
3-4. Adjusting the steering
wheel and mirrors
Steering wheel ..............................169
Inside rear view mirror................ 171
Outside rear view mirrors ........ 173
3-5. Opening, closing
the windows and
moon roof
Power windows ............................. 177
Moon roof ........................................181
Panoramic moon roof ............... 185