Page 45 of 784

451-1. For safe use
ES350_300h_OM_OM33B99U_(U)
1
For safety and security
■If the SRS airbags deploy (inflate)
●Bruising and slight abrasions may result from contact with a deploying (inflating)
SRS airbag.
●A loud noise and white powder will be emitted.
●Parts of the airbag module (steering wheel hub, airbag cover and inflator) as well as
the seats, parts of the front and rear pillars, and roof side rails may be hot for several
minutes. The airbag it self may also be hot.
●The windshield may crack.
●For Lexus Enform Safety Connect subscriber s, if the SRS airbags deploy or in the
event of a severe rear-end collision, the system is designed to send an emergency
call to the response center, notifying them of the vehicle’s location (without needing
to push the “SOS” button) and an agent wi ll attempt to speak with the occupants to
ascertain the level of emergency and assistance required. If the occupants are
unable to communicate, the agent automatically treats the call as an emergency
and helps to dispatch the necessary emergency services. ( P. 5 1 3 )
CAUTION
■Modification and disposal of SRS airbag system components
Do not dispose of your vehicle or perfor m any of the following modifications with-
out consulting your Lexus dealer. The SRS airbags may malfunction or deploy
(inflate) accidentally, causing death or serious injury.
●Installation, removal, disassembl y and repair of the SRS airbags
●Repairs, modifications, removal or replacement of the steering wheel, instrument
panel, dashboard, glove box, seats or seat upholstery, front, side and rear pillars
or roof side rails
●Repairs or modifications of the front fend er, front bumper, or side of the occupant
compartment
●Installation of a grille guard (bull bars, kangaroo bar, etc.), snow plows or winches
●Modifications to the vehicle’s suspension system
●Installation of electronic devices such as mobile two-way radios and CD players
●Modifications to your vehicle for a person with a physical disability
Page 49 of 784
491-1. For safe use
ES350_300h_OM_OM33B99U_(U)
1
For safety and security
●The surface of the seats with the side airbag
is scratched, cracked, or otherwise dam-
aged.
●The portion of the front pillars, rear pillars or
roof side rail garnishes (padding) containing
the curtain shield airbags inside is scratched,
cracked, or otherwise damaged.
Page 56 of 784

561-1. For safe use
ES350_300h_OM_OM33B99U_(U)
CAUTION
■Front passenger occupant classification system precautions
●Do not recline the front passenger seatback so far that it touches a rear seat. This
may cause the “AIR BAG OFF” indicator light to be illuminated, which indicates
that the passenger’s airbags will not deploy in the event of a severe accident. If the
seatback touches the rear seat, return th e seatback to a position where it does
not touch the rear seat. Keep the front passenger seatback as upright as possible
when the vehicle is moving. Reclining the seatback excessively may lessen the
effectiveness of the seat belt system.
●If an adult sits in the front passenger seat, the “AIR BAG ON” indicator light is illu-
minated. If th e “AIR BAG OFF” indicator is illumi nated, ask the passenger to sit
up straight, well back in the seat, feet on the floor, and with the seat belt worn cor-
rectly. If the “AIR BAG OFF” indicator stil l remains illuminated, either ask the pas-
senger to move to the rear seat, or if that is not possible, move the front passenger
seat fully rearward.
●When it is unavoidable to install a forward-facing child restraint system on the
front passenger seat, install the child rest raint system on the front passenger seat
in the proper order. ( P. 6 2 )
●Do not modify or remove the front seats.
●Do not kick the front passenger seat or subject it to severe impact. Otherwise,
the SRS warning light may come on to indi cate a malfunction of the detection sys-
tem. In this case, contact your Lexus dealer immediately.
●Child restraint systems installed on the rear seat should not contact the front seat-
backs.
●Do not modify or replace the upholstery of the front seat.
Page 57 of 784

571-1. For safe use
ES350_300h_OM_OM33B99U_(U)
1
For safety and security
Safety information for children
●It is recommended that children sit in the rear seats to avoid accidental
contact with the shift lever, wiper switch etc.
●Use the rear door child-protector lo ck or the window lock switch to
avoid children opening the door wh ile driving or operating the power
window accidentally. ( P. 145, 177)
●Do not let small children operate eq uipment which may catch or pinch
body parts, such as the power window, hood, trunk, seats etc.
Observe the following precautions when children are in the vehicle.
Use a child restraint system approp riate for the child, until the child
becomes large enough to properly wear the vehicle’s seat belt.
CAUTION
Never leave children unattended in the vehicle, and never allow children to have or
use the key.
Children may be able to start the vehicle or shift the vehicle into neutral. There is
also a danger that children may injure th emselves by playing with the windows, the
moon roof or other features of the vehicle. In addition, heat build-up or extremely
cold temperatures inside the vehicle can be fatal to children.
Page 62 of 784
621-1. For safe use
ES350_300h_OM_OM33B99U_(U)
Installing child restraints
Child restraint LATCH anchors
LATCH anchors are provided for the
outboard rear seats. (Buttons display-
ing the location of the anchors are
attached to the seats.)
Seat belts equipped with a child
restraint locking mechanism (ALR/
ELR belts except driver’s seat belt)
(P. 3 4 )
Anchor brackets (for top tether
strap)
An anchor bracket is provided for
each rear seat.
Follow the child restraint system manufacturer’s instructions. Firmly
secure child restraints to the se ats using the LATCH anchors or a seat
belt. Attach the top tether strap when installing a child restraint.
The lap/shoulder belt can be used if your child restraint system is not
compatible with the LATCH (Lower Anchors and Tethers for Children)
system.
Page 76 of 784

761-2. Hybrid system
ES350_300h_OM_OM33B99U_(U)
■After the 12-volt battery has discharged or has been changed or removed
The gasoline engine may not stop even if the vehicle is running on the hybrid battery
(traction battery). If this continues for a few days, contact your Lexus dealer.
■Sounds and vibrations specific to a hybrid vehicles
There may be no engine sounds or vibration even though the vehicle is able to move.
For safety, apply the parking brake and make sure to shift the shift position to P when
parked.
The following sounds or vibrations may occur when the hybrid system is operating
and are not a malfunction:
●Motor sounds may be heard from the engine compartment.
●Sounds may be heard from the hybrid battery (traction battery) behind the rear
seats when the hybrid system starts or stops.
●Sounds from the hybrid system may be heard when the trunk lid is open.
●Sounds may be heard from the hybrid tran smission when the hybrid system starts
or stops.
●Engine sounds may be heard when accelerating sharply.
●Sounds may be heard due to regenerative braking when the brake pedal is
depressed.
●Vibration may be felt when the gasoline engine starts or stops.
●Cooling fan sounds may be heard from the air intake vent on rear left seat.
■Vehicle proximity notification system
In the following cases, the vehicle proximity notification system may be difficult for
surrounding people to hear.
●In very noisy areas
●In the wind or the rain
Also, as the vehicle proximity notification system is installed on the front of the vehi-
cle, it may be more difficult to hear from the rear of the vehicle compared to the
front.
■Maintenance, repair, recycling, and disposal
Contact your Lexus dealer regarding main tenance, repair, recycling and disposal.
Do not dispose of the vehicle yourself.
■Customization
Settings (e.g. on/off operation of the EV indicator) can be changed.
(Customizable features: P. 7 3 0 )
Page 80 of 784
801-2. Hybrid system
ES350_300h_OM_OM33B99U_(U)
CAUTION
■High voltage precautions
The vehicle has high voltage DC and AC systems as well as a 12-volt system. DC
and AC high voltage is very dangerous and can cause severe burns and electric
shock that may result in death or serious injury.
●Never touch, disassemble, remove or re place the high voltage parts, cables or
their connectors.
●The hybrid system will become hot after starting as the system uses high voltage.
Be careful of both the high voltage and the high temperature, and always obey
the caution labels attached to the vehicle.
●Never try to open the service plug access
hole located behind the rear seats. The ser-
vice plug is used only when the vehicle is
serviced and is subject to high voltage.
Page 123 of 784
123
ES350_300h_OM_OM33B99U_(U)
3
Operation of
each component
3-1. Key information
Keys ................................................... 124
3-2. Opening, closing and locking the doors and trunk
Smart access system with push-button start ............. 127
Wireless remote control ............ 141
Doors ................................................144
Trunk ..................................................149
3-3. Adjusting the seats Front seats .......................................157
Driving position memory ......... 159
Head restraints ............................ 165
3-4. Adjusting the steering wheel and mirrors
Steering wheel ..............................169
Inside rear view mirror................ 171
Outside rear view mirrors ........ 174
3-5. Opening, closing the windows and moon roof
Power windows ............................. 177
Moon roof ........................................181