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TABLE OF CONTENTSIndex
2
IS250C/350C_U
1-1. Key informationKeys ...................................................... 28
1-2. Opening, closing and locking the doors and trunk
Smart access system with push-button start .......................... 32
Wireless remote control .............. 44
Doors.................................................... 47
Trunk...................................................... 51
1-3. Adjustable components (seats, mirrors,
steering wheel)
Front seats .......................................... 55
Driving position memory ............. 61
Seat position memory .................. 65
Head restraints................................. 67
Seat belts ............................................ 70
Steering wheel.................................. 76
Anti-glare inside rear view mirror ................................................ 78
Outside rear view mirrors ........... 79 1-4. Opening and closing the
windows and retractable
hardtop
Power windows................................ 82
Retractable hardtop....................... 86
1-5. Refueling Opening the fuel tank cap........... 95
1-6. Theft deterrent system Engine immobilizer system ......... 98
Alarm.................................................. 100
Theft prevention labels ............... 103
1-7. Safety information Correct driving posture ............. 104
SRS airbags ..................................... 106
Front passenger occupant classification system .................... 117
Child restraint systems ............... 122
Installing child restraints ............. 126
1Before driving
For vehicles with a navigation system, refer to the “Navigation System Owner’s
Manual” for information regarding the equipment listed below.
• Navigation system
• Air conditioning
•Climate control
• Rear view monitor system • Audio/video system
• Rear window and outside rear view
mirror defogging
• Intuitive parking assist
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TABLE OF CONTENTSIndex
6
IS250C/350C_U
5-1. Essential informationEmergency flashers.................... 482
If your vehicle needs to be towed............................................. 483
If you think something is wrong ............................................ 489
Fuel pump shut off system ....... 490
5-2. Steps to take in an emergency If a warning light turns on or a warning buzzer
sounds... .......................................... 491
If a warning message is displayed ...................................... 500
If you have a flat tire (vehicles with standard tires) .................... 513
If you have a flat tire (vehicles with run-flat tires) ...................... 522
If the engine will not start .......... 524
If the shift lever cannot be shifted from P .............................. 526
If you lose your keys .................... 527
If the electronic key does not operate properly .............. 528
If the vehicle battery is discharged ................................... 532
If your vehicle overheats .......... 536
If the vehicle becomes stuck............................................... 539
If the retractable hardtop does not close............................ 540 If your vehicle has to
be stopped in an
emergency .................................. 550
6-1. Specifications Maintenance data (fuel, oil level, etc.)..................... 552
Fuel information ............................ 569
Tire information............................. 573
6-2. Customization Customizable features.............. 586
6-3. Initialization Items to initialize .......................... 590
Reporting safety defects for U.S. owners........................... 592
Seat belt instructions for Canadian owners
(in French) ................................... 593
SRS airbag instructions for Canadian owners
(in French) .................................... 596
Headlight aim instructions for Canadian owners
(in French) ................................... 604
5When trouble arises
6Vehicle specifications
7For owners
Page 10 of 626
IS250C/350C_U
9
Tires
●Rotation
● Replacement
● Inflation pressure
● Information
P. 431
P. 513, 522
P. 563
P. 573
Tail lights P. 176
Trunk P. 51
Rear window defogger *1P. 251
Doors P. 47
Fuel filler door P. 95
Turn signal lights P. 158
Side marker lights P. 176
*1: For vehicles with a navigation system, refe r to the “Navigation System Owner’s Manual”.
Page 19 of 626
IS250C/350C_U
18
Pictorial indexInstrument panel
D
Headlight cleaner switch ∗ P. 189
Trunk opener P. 51
Fuel filler door opener P. 95
Roof switch P. 86
Satellite switches P. 366
Instrument panel lightcontrol dial
P. 162
∗: If equipped
All window control switch P. 82
VSC off switch P. 216
Page 20 of 626

IS250C/350C_U
19
For your information
Main Owner’s Manual
Please note that this manual applies to all models and explains all equipment, includ-
ing options. Therefore, you may find some explanations for equipment not installed
on your vehicle.
All specifications provided in this manual are current at the time of printing. How-
ever, because of the Lexus policy of continual product improvement, we reserve the
right to make changes at any time without notice.
Depending on specifications, the vehicle shown in the illustration may differ from
your vehicle in terms of color and equipment.
Noise from under vehicle after turning off the engine
Approximately five hours after the engine is turned off, you may hear sound coming
from under the vehicle for several minutes. This is the sound of a fuel evaporation
leakage check and, it does not indicate a malfunction.
Accessories, spare parts and modification of your Lexus
A wide variety of non-genuine spare parts and accessories for Lexus vehicles are
currently available in the market. You should know that Toyota does not warrant
these products and is not responsible for their performance, repair, or replacement,
or for any damage they may cause to, or adverse effect they may have on, your
Lexus vehicle.
This vehicle should not be modified with non-genuine Lexus products. Modification
with non-genuine Lexus products could affect its performance, safety or durability,
and may even violate governmental regulations. In addition, damage or perfor-
mance problems resulting from the modification may not be covered under war-
ranty.
Page 21 of 626
IS250C/350C_U
20
Installation of a mobile two-way radio system
The installation of a mobile two-way radio system in your vehicle could affect elec-
tronic systems such as:
●Multiport fuel injection system/sequential multiport fuel injection system
●Cruise control system
●Dynamic radar cruise control system
●Anti-lock brake system
●SRS airbag system
●Seat belt pretensioner system
Be sure to check with your Lexus dealer for precautionary measures or special
instructions regarding installation of a mobile two-way radio system.
Page 28 of 626

Before driving1
27
IS250C/350C_U
1-1. Key informationKeys .............................................. 28
1-2. Opening, closing and locking the doors and
trunk
Smart access system with push-button start ................... 32
Wireless remote control ......... 44
Doors ............................................ 47
Trunk .............................................. 51
1-3. Adjustable components (seats, mirrors,
steering wheel)
Front seats ................................... 55
Driving position memory ......... 61
Seat position memory.............. 65
Head restraints .......................... 67
Seat belts ..................................... 70
Steering wheel........................... 76
Anti-glare inside rear view mirror ......................................... 78
Outside rear view mirrors ...... 79 1-4. Opening and closing the
windows and retractable
hardtop
Power windows .......................... 82
Retractable hardtop ................ 86
1-5. Refueling Opening the fuel tank cap ..... 95
1-6. Theft deterrent system Engine immobilizer system.... 98
Alarm.......................................... 100
Theft prevention labels ......... 103
1-7. Safety information Correct driving posture ....... 104
SRS airbags .............................. 106
Front passenger occupant classification system.............. 117
Child restraint systems ......... 122
Installing child restraints....... 126
Page 96 of 626
95
1
Before driving
IS250C/350C_U
1-5. Refueling
Opening the fuel tank cap
Perform the following steps to open the fuel tank cap.
■Before refueling the vehicle
Turn the “ENGINE START STOP” switch OFF and ensure that both
side doors and windows are closed.
■ Opening the fuel tank cap
Press the opener switch.
Turn the fuel tank cap slowly to
open.
Hang the fuel tank cap on the
back of the fuel filler door.
STEP1
STEP2
STEP3