Page 355 of 461
GMC Sierra/Sierra Denali 1500 Owner Manual (GMNA-Localizing-U.S./
Canada/Mexico-14632426) - 2021 - CRC - 11/5/20
354 Vehicle Care
Lift the cover to access the fuse block.
Caution
Spilling liquid on any electrical
component on the vehicle may damage
it. Always keep the covers on any
electrical component.
A fuse puller is available in the left
instrument panel end cap.
The vehicle may not be equipped with all of
the fuses, relays, and features shown.
Fuses Usage
1 High-beam left
2 High-beam right Fuses
Usage
3 Headlamp left
4 Headlamp right
Page 357 of 461
GMC Sierra/Sierra Denali 1500 Owner Manual (GMNA-Localizing-U.S./
Canada/Mexico-14632426) - 2021 - CRC - 11/5/20
356 Vehicle Care
FusesUsage
65 Auxiliary underhood electrical center
66 Cooling fan motor left 67 Active fuel management 2
68 –
69 Starter Pinion (LD) / Starter Motor (HD Gas)
71 Cooling fan
72 Cooling fan right/Lower
73 Trailer stop/turn lamp left
74 Trailer Interface Module 1
75 DEFC
76 Electric RNG BDS
78 Engine control module
79 Auxiliary battery
80 Cabin cooling pump 81 Trailer stop/turn lamp right Fuses
Usage
82 Trailer Interface Module 2
83 FTZM
84 Trailer brake 85 ENG
86 Engine control module 87 Injector B even
88 O2 B sensor
89 O2 A sensor
90 Injector A odd 91 Engine control module throttle control
92 Cool fan clutch/ Aeroshutter Relays
Usage
5 Headlamp
18 DC/AC inverter
23 Rear window defogger
35 Parking lamp
36 Run/Crank
43 –
59 A/C clutch
64 Starter Motor (LD & HD DSL)
70 Starter Pinion (LD) / Starter Motor (HD Gas)
77 Powertrain
Page 358 of 461
GMC Sierra/Sierra Denali 1500 Owner Manual (GMNA-Localizing-U.S./
Canada/Mexico-14632426) - 2021 - CRC - 11/5/20
Vehicle Care 357
Instrument Panel Fuse Block (Left)
The left instrument panel fuse block access
door is on the driver side edge of the
instrument panel.
The vehicle may not be equipped with all of
the fuses, relays, and features shown.
Pull off the cover to access the fuse block.
A fuse puller is available in the left
instrument panel end cap.
The vehicle may not be equipped with all of
the fuses, relays, and features shown.Fuses Usage
F1 Rear heated seats left/right
F3 –
F4 –
F5 Spare/MFEG
F6 Heated and ventilated seats left/right
F8 –
F9 Passive entry passive start/ Spare
F10 –
F11 –
F12 Passenger power seat
F13 Export power take off/ Special equipment option 1
F14 –
F15 –
F16 AMP F17 –
F18 –
Page 359 of 461
GMC Sierra/Sierra Denali 1500 Owner Manual (GMNA-Localizing-U.S./
Canada/Mexico-14632426) - 2021 - CRC - 11/5/20
358 Vehicle Care
FusesUsage
F20 Endgate F22 Rear sliding window
F23 –
F24 –
F25 –
F26 –
F27 –
Circuit
Breakers Usage
CB1 –
Relays Usage
K1 Rear sliding window open
K2 Rear sliding window close
K3 MFEG major 1
K4 MFEG minor 1 K5 MFEG minor 2
K6 MFEG major 2 K7 –
K8 –Instrument Panel Fuse Block
(Right)
The right instrument panel fuse block access
door is on the passenger side edge of the
instrument panel.
Pull off the cover to access the front of the
fuse block.
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GMC Sierra/Sierra Denali 1500 Owner Manual (GMNA-Localizing-U.S./
Canada/Mexico-14632426) - 2021 - CRC - 11/5/20
Vehicle Care 359
To access the back of the fuse block:
1. Push the tab at the top of fuseblock down.
2. Pull the top of the fuse block outward.
3. Reverse Steps 1–2 to reinstall.
Back
The vehicle may not be equipped with all of
the fuses, relays, and features shown. Fuses Usage
F1 Right doors
F2 Left doors
F3 Universal garage door opener
F4 –
F5 –
F6 Front blower
F8 Lumbar switch
F10 Body control module 6/ Body control module 7
F11 Seat/Column lock module
F12 Body control module 3/ Body control module 5
F14 Mirrors/Windows module F17 Steering wheel controls
F18 Video processing module/ Obstacle detection
F19 DLIS
F20 Ventilated seats F21 NOT R/C
F22 Heated steering wheel
Page 361 of 461

GMC Sierra/Sierra Denali 1500 Owner Manual (GMNA-Localizing-U.S./
Canada/Mexico-14632426) - 2021 - CRC - 11/5/20
360 Vehicle Care
FusesUsage
F23 MISC R/C
F24 Instrument panel cluster ignition/Overhead
F25 Heating, ventilation, and air conditioning ignition/
Heating, ventilation, and
air conditioning auxiliary
F26 USB ports/Special equipment option retained
accessory power
F27 Accessory power outlet/ retained accessory power
F28 Accessory power outlet/ Battery
F30 Sensing and diagnostic module/Parking brake
F31 Body control module 4
F32 Special equipment option/ Data link connection
F33 Body control module 8
F34 Cargo lamp
F40 CGM F41 Infotainment 1 Fuses
Usage
F42 TCP
F43 –
F44 Active vibration management
F45 Body control module 2
F46 Heating, ventilation, and air conditioning/Battery 1
F47 Instrument panel cluster/ Battery
F48 Transmission control module
F49 Body control module 1 F50 –
F51 Battery 1
F52 Battery 2
F53 –
F54 Sunroof F55 Driver power seat
F56 DC DC TRANS 1 F57 DC DC TRANS 2
F58 Infotainment 2 Circuit
Breakers Usage
1 Accessory power outlet 2
2 Accessory power outlet 1/ Cigarette Lighter
3 Accessory power outlet 3
4 Accessory power outlet 4
Relays Usage
K1 Run/Crank
K2 Retained accessory power/ Accessory 1
K4 Retained accessory power/ Accessory 2
K5 –
Wheels and Tires
Tires
Every new GM vehicle has high-quality
tires made by a leading tire
manufacturer. See the warranty manual
for information regarding the tire
Page 442 of 461

GMC Sierra/Sierra Denali 1500 Owner Manual (GMNA-Localizing-U.S./
Canada/Mexico-14632426) - 2021 - CRC - 11/5/20
OnStar 441
.Receive a Diagnostic check of the vehicle's
key operating systems.
.Receive Roadside Assistance.
.Manage Wi-Fi Settings, if equipped.
Press
>to get a priority connection to an
OnStar Advisor available 24/7 to:
.Get help for an emergency.
.Be a Good Samaritan or respond to an
AMBER Alert.
.Get assistance in severe weather or other
crisis situations and find evacuation
routes.
OnStar Services
Emergency
Emergency Services require an active safety
and security plan. With Automatic Crash
Response, built-in sensors can automatically
alert a specially trained OnStar Advisor who
is immediately connected in to the vehicle
to help.
Press
>for a priority connection to an
OnStar Advisor who can contact emergency
service providers, direct them to your exact
location, and relay important information. With OnStar Crisis Assist, specially trained
Advisors are available 24 hours a day, 7 days
a week, to provide a central point of
contact, assistance, and information during a
crisis.
With Roadside Assistance, Advisors can
locate a nearby service provider to help with
a flat tire, a battery jump, or an empty
gas tank.
Security
If equipped, OnStar provides these services:
.With Stolen Vehicle Assistance, OnStar
Advisors can use GPS to pinpoint the
vehicle and help authorities quickly
recover it.
.With Remote Ignition Block, if equipped,
OnStar can block the engine from being
restarted.
.With Stolen Vehicle Slowdown,
if equipped, OnStar can work with law
enforcement to gradually slow the
vehicle down.
Theft Alarm Notification
If equipped, if the doors are locked and the
vehicle alarm sounds, a notification by text,
e-mail, or phone call will be sent. If the
vehicle is stolen, an OnStar Advisor can work
with authorities to recover the vehicle.
OnStar Additional
Information
In-Vehicle Audio Messages
Audio messages may play important
information at the following times:
.Prior to vehicle purchase. PressQto set
up an account.
.After change in ownership and at
90 days.
Transferring Service
PressQto request account transfer
eligibility information. The Advisor can
cancel or change account information.
Selling/Transferring the Vehicle
Call 1-888-4ONSTAR (1-888-466-7827)
immediately to terminate your OnStar or
connected services if the vehicle is disposed
of, sold, transferred, or if the lease ends.