Page 3 of 626

TABLE OF CONTENTSIndex
2
IS250C/350C_U
1-1. Key informationKeys ...................................................... 28
1-2. Opening, closing and locking the doors and trunk
Smart access system with push-button start .......................... 32
Wireless remote control .............. 44
Doors.................................................... 47
Trunk...................................................... 51
1-3. Adjustable components (seats, mirrors,
steering wheel)
Front seats .......................................... 55
Driving position memory ............. 61
Seat position memory .................. 65
Head restraints................................. 67
Seat belts ............................................ 70
Steering wheel.................................. 76
Anti-glare inside rear view mirror ................................................ 78
Outside rear view mirrors ........... 79 1-4. Opening and closing the
windows and retractable
hardtop
Power windows................................ 82
Retractable hardtop....................... 86
1-5. Refueling Opening the fuel tank cap........... 95
1-6. Theft deterrent system Engine immobilizer system ......... 98
Alarm.................................................. 100
Theft prevention labels ............... 103
1-7. Safety information Correct driving posture ............. 104
SRS airbags ..................................... 106
Front passenger occupant classification system .................... 117
Child restraint systems ............... 122
Installing child restraints ............. 126
1Before driving
For vehicles with a navigation system, refer to the “Navigation System Owner’s
Manual” for information regarding the equipment listed below.
• Navigation system
• Air conditioning
•Climate control
• Rear view monitor system • Audio/video system
• Rear window and outside rear view
mirror defogging
• Intuitive parking assist
Page 6 of 626

1
2
3
4
5
6
7
5
IS250C/350C_U
3-6. Using the storage featuresList of storage features............... 356
• Glove box .................................... 357
• Console box ............................... 358
• Cup holders................................. 359
• Auxiliary box ............................... 362
3-7. Other interior features Sun visors......................................... 363
Vanity mirror .................................. 364
Clock ................................................. 365
Satellite switches .......................... 366
Ashtrays ........................................... 369
Cigarette lighter ........................... 370
Power outlet .................................... 371
Seat heaters and ventilators ..................................... 372
Floor mat.......................................... 374
Trunk features................................ 375
Garage door opener.................. 378
Compass......................................... 384
Safety Connect ............................ 388 4-1. Maintenance and care
Cleaning and protecting the vehicle exterior................... 396
Cleaning and protecting the vehicle interior ..................... 401
4-2. Maintenance Maintenance requirements ..... 404
General maintenance ................ 406
Emission inspection and maintenance (I/M)
programs ...................................... 409
4-3. Do-it-yourself maintenance Do-it-yourself service precautions ................................... 410
Hood .................................................. 413
Positioning a floor jack................ 414
Engine compartment................... 416
Tires .................................................... 431
Tire inflation pressure.................. 441
Wheels ............................................. 445
Air conditioning filter.................. 447
Electronic key battery ................ 449
Checking and replacing fuses ................................................. 451
Headlight aim ................................ 466
Light bulbs....................................... 468
4Maintenance and care
Page 10 of 626
IS250C/350C_U
9
Tires
●Rotation
● Replacement
● Inflation pressure
● Information
P. 431
P. 513, 522
P. 563
P. 573
Tail lights P. 176
Trunk P. 51
Rear window defogger *1P. 251
Doors P. 47
Fuel filler door P. 95
Turn signal lights P. 158
Side marker lights P. 176
*1: For vehicles with a navigation system, refe r to the “Navigation System Owner’s Manual”.
Page 15 of 626
IS250C/350C_U
14
Pictorial indexInstrument panel
Headlight switch Turn signal lever
Fog light switch P. 176
P. 158
P. 180
Shift paddle switches P. 155
Gauges and meters P. 161
Multi-information display P. 171
Windshield wiper and washer switch P. 182
Engine (ignition) switch P. 147
Trunk opener main switch P. 51
Tilt and telescopic steering control switch P. 76
Audio remote control switches *1P. 300
Horn P. 160Glove box P. 357
Parking brake pedal P. 159
Hood lock release lever P. 413
Inside door lock buttons P. 47
Page 19 of 626
IS250C/350C_U
18
Pictorial indexInstrument panel
D
Headlight cleaner switch ∗ P. 189
Trunk opener P. 51
Fuel filler door opener P. 95
Roof switch P. 86
Satellite switches P. 366
Instrument panel lightcontrol dial
P. 162
∗: If equipped
All window control switch P. 82
VSC off switch P. 216
Page 28 of 626

Before driving1
27
IS250C/350C_U
1-1. Key informationKeys .............................................. 28
1-2. Opening, closing and locking the doors and
trunk
Smart access system with push-button start ................... 32
Wireless remote control ......... 44
Doors ............................................ 47
Trunk .............................................. 51
1-3. Adjustable components (seats, mirrors,
steering wheel)
Front seats ................................... 55
Driving position memory ......... 61
Seat position memory.............. 65
Head restraints .......................... 67
Seat belts ..................................... 70
Steering wheel........................... 76
Anti-glare inside rear view mirror ......................................... 78
Outside rear view mirrors ...... 79 1-4. Opening and closing the
windows and retractable
hardtop
Power windows .......................... 82
Retractable hardtop ................ 86
1-5. Refueling Opening the fuel tank cap ..... 95
1-6. Theft deterrent system Engine immobilizer system.... 98
Alarm.......................................... 100
Theft prevention labels ......... 103
1-7. Safety information Correct driving posture ....... 104
SRS airbags .............................. 106
Front passenger occupant classification system.............. 117
Child restraint systems ......... 122
Installing child restraints....... 126
Page 31 of 626

30
1-1. Key information
IS250C/350C_U
●The card key is not waterproof.
■When required to leave a key to the vehicle with a parking attendant
Turn the trunk opener main switch off and lock the glove box as circumstances
demand. (→P. 5 1 , 3 5 7 )
Remove the mechanical key for your own use and provide the attendant with the
electronic key only.
■Key number plate
Keep the plate in a safe place such as your wallet, not in the vehicle. In the event that
a mechanical key is lost, a new key can be made at your Lexus dealer using the key
number plate. ( →P. 5 2 7 )
■When riding in an aircraft
When bringing an electronic key onto an aircraft, make sure you do not press any
buttons on the electronic key while inside the aircraft cabin. If you are carrying an
electronic key in your bag etc, ensure that the buttons are not likely to be pressed
accidentally. Pressing a button may cause the electronic key to emit radio waves
that could interfere with the operation of the aircraft.
●If the battery cover is not installed and
the battery falls out or if the battery was
removed because the key got wet, rein-
stall the battery with the positive termi-
nal facing the Lexus emblem.
Page 33 of 626
32
IS250C/350C_U
1-2. Opening, closing and locking the doors and trunk
Smart access system with push-button start
The following operations can be performed simply by carrying the elec-
tronic key (including the card key∗) on your person, for example in your
pocket.
(The driver should always carry the electronic key.)
Locks and unlocks the doors ( →P. 3 3 )
Unlocks the trunk ( →P. 3 3 )
Starts the engine ( →P. 147)
∗
: If equipped
Electronic key
Electronic key
Electronic key