Page 677 of 917
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6-3. Do-it-yourself maintenance
CAUTION
■When working near the electric cooling fans or radiator grille
Be sure the “START STOP ENGINE” <“POWER”> switch is off.
With the “START STOP ENGINE” <“PO WER”> switch in IGNITION ON
mode, the electric cooling fans may automatically start to run if the air conditioning
is on and/or the coolant temperature is high. ( P. 6 9 1 )
■Safety glasses
Wear safety glasses to prevent flying or falling material, fluid spray, etc. from get-
ting in your eyes.
NOTICE
■If you remove the air cleaner filter
Driving with the air cleaner filter removed may cause excessive engine wear due to
dirt in the air.
Page 712 of 917

ES350_300h_OM_OM33A60U_(U)
7116-3. Do-it-yourself maintenance
6
Maintenance and care
NOTICE
■Repairing or replacing tires, wheels, tire pressure warning valves, transmitters
and tire valve caps
●When removing or fitting the wheels, tires or the tire pressure warning valves and
transmitters, contact your Lexus dealer as the tire pressure warning valves and
transmitters may be damaged if not handled correctly.
●Make sure to install the tire valve caps. If the tire valve caps are not installed,
water could enter the tire pressure warning valves and the tire pressure warning
valves could be bound.
●When replacing tire valve caps, do not us e tire valve caps other than those speci-
fied. The cap may become stuck.
■To avoid damage to the tire pressu re warning valves and transmitters
When a tire is repaired with liquid seal ants, the tire pressure warning valve and
transmitter may not operate properly. If a liquid sealant is used, contact your Lexus
dealer or other qualified service shop as soon as possible. Make sure to replace
the tire pressure warning valve and transmitter when replacing the tire. ( P. 7 0 3 )
■Driving on rough roads
Take particular care when driving on roads with loose surfaces or potholes.
These conditions may cause losses in tire inflation pressure, reducing the cushion-
ing ability of the tires. In addition, driving on rough roads may cause damage to the
tires themselves, as well as the vehicle’s wheels and body.
■Low profile tires (P225/45R18 tires)
Low profile tires may cause greater damage than usual to the tire wheel when sus-
taining impact from the road surface. Th erefore, pay attention to the following:
●Be sure to use proper tire inflation pressure. If tires are under-inflated, they may
be damaged more severely.
●Avoid potholes, uneven pavement, curbs and other road hazards. Failure to do so
may lead to severe tire and wheel damage.
■If tire inflation pressure of each tire becomes low while driving
Do not continue driving, or your tires and/or wheels may be ruined.
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ES350_300h_OM_OM33A60U_(U)
6-3. Do-it-yourself maintenance
■Instructions for checking tire inflation pressure
When checking tire inflation pressure, observe the following:
●Check only when the tires are cold.
If your vehicle has been parked for at least 3 hours or has not been driven for more
than 1 mile or 1.5 km, you will get an accurate cold tire inflation pressure reading.
●Always use a tire pressure gauge.
The appearance of the tire can be misleading. In addition, tire inflation pressure that
is even just a few pounds off can affect ride quality and handling.
●Do not reduce tire inflation pressure after driving. It is normal for tire inflation pres-
sure to be higher after driving.
●Never exceed the vehicle capacity weight.
Passengers and luggage weight should be placed so that the vehicle is balanced.
CAUTION
■Proper inflation is critical to save tire performance
Keep your tires properly inflated. Otherwise, the following conditions may occur
and result in an accident causing death or serious injury:
●Excessive wear
●Uneven wear
●Poor handling
●Possibility of blowouts resulting from overheated tires
●Poor sealing of the tire bead
●Wheel deformation and/or tire separation
●A greater possibility of tire damage from road hazards
NOTICE
■When inspecting and adjusting tire inflation pressure
Be sure to put the tire valve caps back on.
Without the valve caps, dirt or moisture could get into the valve and cause air leak-
age, which could result in an accident. If the caps are lost, replace them as soon as
possible.
Page 718 of 917
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6-3. Do-it-yourself maintenance
6
Maintenance and care
Air conditioning filter
Turn the “START STOP ENGINE” <“POWER”> switch off.
Open the glove box. Lift and
remove the partition.
Remove the glove box cover.
Remove the filter cover.
The air conditioning filter must be changed regularly to maintain air
conditioning efficiency.
Removal method
1
2
3
4
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ES350_300h_OM_OM33A60U_(U)
6-3. Do-it-yourself maintenance
Slide and pull out the filter.
Replace it with a new one.
The “UP” marks shown on the filter
should be pointing up.
■Changing interval
Inspect and replace the air conditioning f ilter according to the maintenance sched-
ule. In dusty areas or areas with heavy traffic flow, early replacement may be
required. (For scheduled maintenance information, please refer to the “Owner’s
Manual Supplement” or “S cheduled Maintenance”.)
■If air flow from the vents decreases dramatically
The filter may be clogged. Check the filter and replace if necessary.
5
NOTICE
■When using the air conditioning system
Make sure that a filter is always installed.
Using the air conditioning system without a filter may cause damage to the system.
Page 726 of 917
ES350_300h_OM_OM33A60U_(U)
7256-3. Do-it-yourself maintenance
6
Maintenance and care
FuseAmpereCircuit
1WIP-S5Driver support system, windshield wipers
2FA N50Electric cooling fan
3H-LP CLN30No circuit
4ENG W/PMP*130Cooling system
5PTC HTR NO.250PTC heater
6PTC HTR NO.150PTC heater
7HTR50Air conditioning system
8ALT*2140Charging system
DC/DC*1120Hybrid system
9ABS NO.2*230VSC, ABS
10ST/AM2*230Starting system
ABS NO.1*130VSC, ABS
11H-LP-MAIN30H-LP RH-LO, H-LP LH-LO
12ABS MTR NO.2*150VSC, ABS
13ABS NO.1*250VSC, ABS
ABS MTR NO.1*150VSC, ABS
14R/B NO.2*150IGCT MAIN, INV W/PMP
15EPS80Electric power steering
16S-HORN7. 5S-HORN
17DEICER15Windshield wiper de-icer
18HORN10Horn
19TV15
Multi-information display, audio display,
Remote Touch, audio system, gauges and
meters
20AMP NO.230Audio system
21EFI NO.215
Multiport fuel injection system, sequential
multiport fuel system, electronic controlled
transmission
Page 730 of 917

ES350_300h_OM_OM33A60U_(U)
7296-3. Do-it-yourself maintenance
6
Maintenance and care
■Driver’s side instrument panel
FuseAmpereCircuit
1ECU-IG1 NO.210
Main body ECU, audio system, shift lock sys-
tem, outside mirror control ECU, tension
reducer, windshield wipers, heated steering
wheel, multi-information display, audio dis-
play, intuitive parking assist, tire pressure
warning system, moon roof, auto anti-glare
inside rear view mirror, raindrop sensor, rear
sunshade, wireless door lock system, power
trunk opener and closer ECU
2ECU-IG1 NO.110
Electric cooling fan, windshield wiper de-
icer, VSC, ABS, charging system, steering
sensor, electronic controlled transmission,
electric power steering, gateway ECU, elec-
tric tilt and telescopic steering column
3PA N E L N O. 25Clock
4TA I L15Parking lights, side marker lights, license
plate lights
5DOOR F/R20Power window, outside mirror control ECU
6DOOR R/R20Po w e r w i n d o w
7DOOR F/L20Power window, outside mirror control ECU
8DOOR R/L20Po w e r w i n d o w
9H-LP LVL7. 5Automatic headlight leveling system
10WA S H E R10Windshield washer
11A/C-IG17. 5Air conditioning system, PTC heater, gauges
and meters, seat heaters and ventilators
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ES350_300h_OM_OM33A60U_(U)
6-3. Do-it-yourself maintenance
12WIPER25Windshield wipers
13BKUP LP7. 5
Multiport fuel injection system, sequential
multiport fuel system, electronic controlled
transmission, audio system, navigation sys-
tem, back-up lights
14FUEL OPN10Fuel filler door opener
15EPS-IG110Electric power steering
16P/O U T L E T R R15Po w e r o u t l e t
17RADIO-ACC5Audio system, Remote Touch, multi-informa-
tion display, audio display, navigation system
18S/HTR&FAN F/R10Seat heaters and ventilators
19S/HTR&FAN F/L10Seat heaters and ventilators
20OBD7. 5On-Board diagnosis system
21ECU-B NO.210
Power window master switch, air condition-
ing system, smart access system with push-
button start, tire pressure warning system,
rear sunshade
22STRG HTR10Heated steering wheel
23PTL25Power trunk opener and closer ECU
24STOP7. 5
Power management system, multiport fuel
injection system, sequential multiport fuel
system, VSC, ABS, electronic controlled
transmission, driver support system, engine
room junction block assy, tail lights, high
mounted stoplight, smart access system with
push-button start, shift lock system
25P/ S E AT F/ L30Po w e r s e a t s
26A/C-B7. 5Air conditioning system
27S/ROOF10Moon roof
28P/ S E AT F/ R30Po w e r s e a t s
29PSB30Pre-collision seat belt
30D/L-AM120Main body ECU, power door lock system
FuseAmpereCircuit