
ATTENTION ASSIST ........................... 178
Messages in the multifunction
display  ........................................... 292
Switching on or off ......................... 138
Audio menu  ........................................ 134
Auto-dimming rear view mirrors  ........ 95
Automatic central locking  .......... 80, 144
Automatic climate control see Climate control system                      
Automatic headlamp mode  ................ 98
Automatic interior lighting control  .. 103
Automatic locking when driving  ...... 144
Automatic shift program  .................. 120
Automatic transmission  ................... 114
Automatic shift program  ................120
Gear range indicator  ......................120
Gear ranges  ................................... 120
Gear selector lever  ........................115
Hill-start assist system  ..................160
Kickdown  ....................................... 119
Kickdown (manual shift program)  ..124
Manual shift program ..................... 122
One-touch gearshifting  ..................121
Program mode indicator  ................121
Program mode selector dial
(E 63 AMG)  ............................ 121, 123
Program mode selector switch
(automatic shift program)  ..............120
Shifting procedure  .........................118
Steering wheel gearshift control  ....122
Transmission position indicator  .....118
Transmission positions  ..................118
AUX socket  ........................................ 201
Axle oils  .............................................. 360
B
BabySmart™  
Air bag deactivation system  .............46
Self-test  ........................................... 47
Backrest
see Seats                                                  
Backup lamps  
Messages in the multifunction
display  ........................................... 300
Bar (air pressure unit)  ....................... 250
BAS (Brake Assist System)  ................. 63
BAS PLUS (Brake Assist System
PLUS)  .................................................... 63
Batteries, SmartKey  
Checking condition  ..........................79
Replacing  ....................................... 317
Battery, Vehicle  ................................. 336
Charging  ........................................ 337
Jump starting  ................................. 338
Messages in the multifunction
display  ................................... 284, 297
Bead (tire)  .......................................... 250
Beverage holders see Cup holders                                        
Bleeding the fuel system (diesel
engine)  ............................................... 333
Blind Spot Assist  ............................... 175
Messages in the multifunction
display  ........................................... 281
Switching on or off ......................... 138
BlueTEC  
AdBlue ®
 tank  ................................. 333
Brake Assist System
see BAS                                                     
Brake Assist System PLUS
see BAS PLUS                                           
Brake fluid  
Checking level  ............................... 227
Messages in the multifunction
display  ........................................... 289
Brake lamps  
Cleaning lenses  ............................. 262
Brake pads  
Messages in the multifunction
display  ........................................... 287
Brakes  ................................................ 254
Ceramic brake system  ...................256
High-performance brake system  ....256
Parking brake  ................................ 113
Warning lamp ................................. 305
Break-in period  .................................. 220
Bug cover (Radiator)  ......................... 224
Bulbs see Replacing bulbs                                  Index5212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 5 

ESC (Electronic Stability Control) ...... 65
ETS/4-ETS  ....................................... 65
Messages in the multifunction
display  ........................... 288, 289, 290
Warning lamp ................................. 309
ETD (Emergency Tensioning
Device)  ................................................. 52
Safety guidelines  ............................. 39
ETS/4-ETS (Electronic Traction
System)  ................................................ 65
Express operation  
Panorama roof  ............................... 195
Power windows  .............................. 105
Tilt/sliding sunroof  ........................192
Exterior lamp switch  ........................... 97
Exterior rear view mirrors  .................. 95
Parking position  ............................... 95
Exterior view of vehicle  ...................... 26
F
Fastening the seat belts  ..................... 50
First aid kit  ......................................... 268
Flat tire  ............................................... 323
Lowering the vehicle  ......................328
Mounting the spare wheel  .............323
Preparing the vehicle  .....................323
Spare wheel ........................... 323, 358
TIREFIT (tire repair kit)  ...................329
Floormats  ........................................... 217
Fluids  
Automatic transmission fluid  .........360
Brake fluid  ..................................... 361
Capacities  ...................................... 359
Engine coolant  ............................... 361
Engine oil  ....................................... 360
Power steering fluid  .......................360
Washer and headlamp cleaning
system  ........................................... 361
Fog lamps  ............................................. 99
Messages in the multifunction
display  ................................... 300, 302
Four-wheel drive
see All-wheel drive (4MATIC)                    
Front air bags
see Air bags                                              
Front axle oil  ...................................... 360
Front lamps
see Headlamps                                         
Front passenger front air bag  ............ 40
Messages in the multifunction
display  ........................................... 276
Front passenger front air bag off
indicator lamp (Canada only)  ..... 46, 313
Front passenger front air bag off
indicator lamp (USA only)  .......... 43, 314
Fuel  ..................................................... 220
Additives  ........................................ 364
Capacity, fuel tank  .........................361
Diesel fuel  ...................................... 363
Drive sensibly–safe fuel  .................254
Fuel consumption statistics  ...........130
Fuel filler flap and cap  ...................222
Fuel tank reserve warning lamp  .....310
Premium unleaded gasoline  ...........362
Refueling ........................................ 220
Requirements  ................................ 363
Fuel filler flap  ..................................... 222
Opening manually  ..........................316
Fuel gauge  ......................................... 126
Fuels, coolants, lubricants etc.  ........ 359
Fuel system, bleeding (diesel
engine)  ............................................... 333
Fuel tank  
Capacity  ........................................ 361
Fuel filler flap and cap  ...................222
Refueling ........................................ 220
Fuses  .................................................. 343
G
Garage door opener  .................... 33, 212
Gasoline see Fuel                                                     
GAWR (Gross Axle Weight Rating)  ... 250
Gear range  ......................................... 120
Indicator  ........................................ 120
Limiting  .......................................... 122
Shifting into optimal  ......................122
Gear selector lever  ............................ 115
Cleaning ......................................... 265
Gearshift pattern  ........................... 115
Shifting procedure  .........................118
Transmission position indicator  .....118
Transmission positions  ..................118
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SRS .......................................... 36, 308
Turn signals  ..................................... 29
Lane Keeping Assist  .......................... 177
Messages in the multifunction
display  ........................................... 283
Switching on or off ......................... 138
LATCH-type child seat anchors (ISOFIX)
see Children in the vehicle                        
License plate lamps  
Messages in the multifunction
display  ........................................... 301
Light alloy wheels, cleaning  ............. 265
Lighter see Cigarette lighter                                 
Lighting  ................................................ 97
Daytime running lamp mode  ............98
Exterior  ............................................ 97
Interior  ........................................... 103
Limp-home mode  .............................. 124
Load index (tires)  ...................... 246, 250
Loading see Vehicle loading                                   
Locator lighting  ................................. 142
Locking the vehicle  
KEYLESS-GO  .................................... 77
Manually  ........................................ 315
SmartKey  ......................................... 76
Loss of  
Key  .................................................. 79
Service and Warranty Information
booklet  .......................................... 346
Low-beam headlamps  ......................... 98
Exterior lamp switch  ........................97
Indicator lamp .................................. 30
Replacing bulbs  ............................. 319
Switching on  .................................... 98
Lubricants  .......................................... 359
Lumbar support  ................................... 89
M
Maintenance  ........................................ 21
Maintenance System  
Service indicator display  ................259
Service indicator message  .............258
Service term exceeded  ..................259
Manual headlamp mode (Low-
beam headlamps)  ................................ 98
Manual shift program  ....................... 122
Maximum engine speed see Vehicle specification                          
Maximum loaded vehicle weight  ..... 250
Maximum load rating (tires)  ............. 250
Maximum permissible tire
inflation pressure  .............................. 251
Mechanical key see Key, Mechanical                                 
Media interface  ................................. 201
Memory function  ................................. 96
Menus see Control system menus                       
Minispare wheel
see Spare wheel                                        
Mirrors  .................................................. 94
Auto-dimming rear view mirrors ....... 95
Exterior rear view mirror parking
position  ............................................ 95
Exterior rear view mirrors  ................95
Interior rear view mirror  ...................94
Memory function .............................. 96
Vanity mirror  .................................. 205
MOExtended system  ......................... 329
MOExtended tires  ..................... 329, 353
MON (Motor Octane Number)  .......... 363
Motor Octane Number see MON                                                   
Multifunction display  ........................ 128
Symbol messages  ..........................287
Text messages  ............................... 274
Vehicle status messages  ...............272
Multifunction display messages  
ABS  ....................................... 288, 289
Active headlamps  .......................... 299
Advanced TPMS  ............................. 285
Air bags  ......................................... 276
Air filter .......................................... 299
AIRMATIC  ...................................... 292
Alternator  .............................. 284, 297
ATTENTION ASSIST  ........................292
Automatic
transmission  .......................... 283, 284
Backrests ....................................... 293
Battery  ................................... 284, 297
Blind Spot Assist ............................ 281
Brake fluid  ..................................... 28912Index212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 12 

Brake pads ..................................... 287
Child seat  ...................................... 279
Coolant  .......................................... 295
Corner-illuminating lamps  ..............303
Cruise control  ................................ 279
DISTRONIC PLUS  ........................... 280
Doors  ............................................. 293
EBP  ................................................ 289
Engine oil  ....................................... 298
ESC  ............................... 288, 289, 290
Fog lamps  .............................. 300, 302
Front passenger front air bag  ........276
Gas cap .......................................... 298
High-beam lamps  ........................... 301
Hood  .............................................. 293
Lane Keeping Assist  ......................283
License plate lamps  .......................301
Light sensor  ................................... 302
Low-beam lamps ............................ 302
Parking brake  ................................ 289
Parking lamps  ................................ 301
Power steering  ............................... 295
PRE-SAFE ®
 .................................... 274
Radar sensors  ................................ 282
Reserve fuel  ................................... 298
Reverse lamp  ................................. 300
Side marker lamps  .........................300
SmartKey  ....................................... 293
SRS  ................................................ 290
Tele Aid  .......................................... 290
Tire inflation pressure  ............284, 304
Tire pressure monitor  ....................285
Tires  ...................................... 284, 304
Trunk  ............................................. 293
Turn signals  ................................... 303
Washer fluid  ................................... 294
Multifunction steering wheel  
Adjustment  ...................................... 93
Buttons  .......................................... 126
Cleaning ......................................... 265
Easy-entry/exit feature  ...........93, 145
Gearshift control  ............................ 122
Heating  ............................................ 94
Memory function .............................. 96
Overview  .......................................... 30N
Navigation system see Separate operating instructions         
Navi menu  .......................................... 134
NECK-PRO active front head
restraints  ............................................. 54
Resetting  ....................................... 316
Nets, parcel  ....................................... 199
Night View Assist Plus  ...................... 172
Cleaning the windshield in front of
the camera  .................................... 263
Normal occupant weight  .................. 251
Number, vehicle identification
(VIN)  ................................................... 346
O
Occupant Classification System see OCS (Occupant Classification
System)                                                     
Occupant distribution  ....................... 251
Occupant safety  
Air bags  ........................................... 37
BabySmart™  .................................... 46
Children and air bags  .......................37
Children in the vehicle  .....................56
Child seat anchors – LATCH-type
(ISOFIX)  ........................................... 59
Fastening the seat belts ................... 50
Front passenger front air bag off
indicator lamp (Canada
only)  ........................................ 46, 313
Front passenger front air bag off
indicator lamp (USA only)  ........43, 314
Infant and child restraint systems .... 56
Introduction  ..................................... 36
ISOFIX (Child seat anchors –
LATCH-type) ..................................... 59
OCS (Occupant Classification
System)  ........................................... 43
PRE-SAFE ®
 ....................................... 53
Seat belts  .................................. 39, 48
OCS (Occupant Classification
System)  ................................................ 43
Self-test  ........................................... 46
Odometer  ........................................... 129
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T
Tachometer  .................................. 28, 126
Overspeed range  ........................... 126
Tail lamps  
Cleaning lenses  ............................. 262
Tar stains  ........................................... 261
Technical data  
Air conditioning refrigerant  ............362
Brake fluid  ..................................... 362
Capacities fuels, coolants,
lubricants etc.  ................................ 359
Coolant  .......................................... 365
Engine oil additives  ........................362
Engine oils  ..................................... 361
Fuel requirements .......................... 363
Gasoline additives .......................... 364
Identification labels  .......................346
Premium unleaded gasoline  ...........362
Rims and tires  ................................ 353
Spare wheel  ................................... 358
Vehicle specification E 350 ............ 348
Vehicle specification
E 350 4MATIC ................................ 349
Vehicle specification
E 350 BlueTEC  ............................... 348
Vehicle specification E 550 ............ 350
Vehicle specification
E 550 4MATIC ................................ 351
Vehicle specification E 63 AMG  .....352
Washer and headlamp cleaning
system  ................................... 361, 367
Technical data (dimensions)
see Vehicle specification                          
Technical data (electrical system)
see Vehicle specification                          
Technical data (engine)
see Vehicle specification                          
Technical data (weights)
see Vehicle specification                          
Tele Aid  ............................................... 207
Emergency calls  ............................. 208
Information button  .........................210
Initiating an emergency call
manually  ........................................ 209
Messages in the multifunction
display  ........................................... 290
Remote door lock  .......................... 212Remote door unlock  ......................211
Roadside Assistance button  ..........210
Search & Send  ............................... 211
SOS button  .................................... 209
Stolen Vehicle Recovery Services  ..212
System self-test  ............................. 208
Telephone  ............................................. 30
Answering/ending a call  ................136
Hands-free microphone  ...................33
Menu  ............................................. 135
Operation ....................................... 135
Phone book .................................... 136
Redialing  ........................................ 137
Temperature  
Coolant  .......................................... 125
Interior temperature  ......................186
Outside  .......................................... 126
Tether anchorage points
see Children in the vehicle                        
Through-loading feature  ................... 198
Tie-down rings  ................................... 199
Tightening torque  
Wheels  ........................................... 328
TIN (Tire Identification Number)  ...... 251
Tire and Loading Information
placard  ............................................... 237
Tire and loading terminology  ........... 249
TIREFIT  ............................................... 329
Tire Identification Number see TIN                                                      
Tire inflation pressure  
Checking ........................................ 231
Important notes on  ........................230
Label on the inside of fuel filler
flap  ................................................ 230
Placard on driver’s door B-pillar  .....237
Tire labeling  ....................................... 245
Tire load rating  .................................. 250
Tire ply composition and material
used  .................................................... 251
Tire pressure loss warning system  . 232
Tire repair kit see TIREFIT                                               
Tires  ........................................... 228, 353
Advanced Tire Pressure
Monitoring System (Advanced
TPMS)  ............................................ 233Index17212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 17 

Air pressure ................................... 229
Care and maintenance  ...................242
Cleaning ......................................... 243
Direction of rotation, spinning  .......241
Important notes on tire inflation
pressure  ........................................ 230
Inflation pressure  ........................... 231
Information placard  .......................237
Inspection  ...................................... 242
Labeling  ......................................... 245
Load index  ............................. 246, 250
Load rating  .................................... 250
Messages in the multifunction
display  ................................... 284, 304
MOExtended  .................................. 353
Ply composition and material
used ............................................... 251
Problems under-/overinflation  ......231
Retreads  ........................................ 228
Rims and tires (technical data)  ......353
Rotation  ......................................... 244
Service life  ..................................... 242
Sizes  .............................................. 353
Snow chains  .................................. 252
Speed rating  .......................... 247, 251
Storing  ........................................... 243
Temperature  .......................... 230, 244
Terminology  ................................... 249
TIREFIT (tire repair kit)  ...................329
Tire Identification Number  .............251
Tire pressure loss warning system . 232
TPMS low tire pressure/
malfunction telltale  ........................312
Traction  ................................. 244, 251
Tread  ............................................. 251
Tread depth  ........................... 242, 252
Treadwear  ...................................... 243
Treadwear indicators  .............242, 252
Vehicle maximum load on  ..............252
Wear pattern  .................................. 244
Winter tires  ............................ 252, 353
Tire speed rating  ....................... 247, 251
Top tether see Children in the vehicle                        
Total load limit  ................................... 251
Towing  
Towing eye bolt .............................. 341
Vehicle  ........................................... 340Towing eye bolt ................................. 341
Traction  ...................................... 244, 251
Transfer case  ..................................... 124
Transmission see Automatic transmission                     
Transmission fluid level  .................... 226
Transmission gear selector lever see Gear selector lever                             
Transmission positions  .................... 118
Traveling abroad  ............................... 257
Tread (tires)  ....................................... 251
Tread depth (tires)  .................... 242, 252
Treadwear  .......................................... 243
Treadwear indicators (tires)  .... 242, 252
Trip menu  ........................................... 129
Trunk  
Closing  ............................................. 82
Fuse box  ........................................ 343
Messages in the multifunction
display  ........................................... 293
Opening  ........................................... 82
Opening/closing system .................. 83
Tie-down rings  ............................... 199
Trunk lid emergency release  ............84
Unlocking manually  .......................315
Valet locking  .................................... 85
Turning off the engine  ...................... 113
Turn signals  ....................................... 100
Cleaning lenses  ............................. 262
Indicator lamps  ................................ 29
Messages in the multifunction
display  ........................................... 303
Replacing bulbs  ............................. 319
U
Uniform Tire Quality Grading
Standards  .................................. 243, 252
Units  
Selecting speedometer display
mode  ............................................. 141
Unleaded gasoline, premium  ........... 362
Unlocking the vehicle  
KEYLESS-GO  .................................... 77
Manually  ........................................ 314
SmartKey  ......................................... 76
Upholstery, cleaning  ......................... 266
Useful features  .................................. 203
18Index212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 18 

V
Valet locking  ........................................ 85
Vehicle  
Battery  ........................................... 336
Care  ............................................... 260
Control system  .............................. 126
Identification Number (VIN)  ...........346
Locking/unlocking ........................... 76
Lowering (wheel change)  ...............328
Modifications and alterations,
Operating safety  .............................. 22
Towing  ........................................... 340
Unlocking/locking manually  ..........314
Vehicle dimensions
see Vehicle specification                          
Vehicle Identification Number
(VIN)  ................................................... 346
Vehicle jack see Jack                                                     
Vehicle level control
see AIRMATIC                                           
Vehicle lighting  .................................... 97
Vehicle loading  
Cargo tie-down rings ...................... 199
Instructions .................................... 197
Load limit  ....................................... 238
Roof rack  ....................................... 198
Split rear seat bench  .....................199
Terminology  ................................... 249
Vehicle maximum load on the tire  ... 252
Vehicle specification  
E 350  ............................................. 348
E 350 4MATIC ................................ 349
E 350 BlueTEC  ............................... 348
E 550  ............................................. 350
E 550 4MATIC ................................ 351
E 63 AMG  ...................................... 352
Vehicle status message memory  .... 139
Vehicle tool kit  .................................. 268
Vehicle washing see Vehicle care                                        
Vehicle weights
see Vehicle specification                          W
Warning sounds  
DISTRONIC PLUS  ........................... 151
Driver’s or passenger’s seat belt  .....52
Parking brake  ................................ 289
Parking Guidance ........................... 170
Parktronic system  ..........................168
Seat belt telltale  ............................ 307
Warranty coverage  ............................ 346
Washer and headlamp cleaning
system  ................................................ 367
Washer fluid  
Messages in the multifunction
display  ........................................... 294
Mixing ratio  .................................... 367
Refilling  .......................................... 227
Washing the vehicle  .......................... 260
Wear pattern (tires)  .......................... 244
Weights (vehicle) see Vehicle specification                          
Wheel  
Changing  ....................................... 323
Removing  ....................................... 326
Spare  ............................................. 323
Tightening torque ........................... 328
Wheels, sizes  ..................................... 353
Wheels, Tires and  .............................. 228
Window curtain air bags  ..................... 42
Windows see Power windows                                  
Windows, cleaning  ............................ 264
Windshield  
Cleaning wiper blades .................... 264
Washer fluid  ................................... 367
Wipers  ........................................... 104
Windshield wipers  
Replacing wiper blades  ..................322
Winter cover  .............................. 224, 252
Winter driving  
Instructions .................................... 253
Radiator cover  ............................... 252
Snow chains  .................................. 252
Tires ............................................... 252
Winter tires  ................................ 252, 353
Wood trims, cleaning  ........................ 266Index19212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 19 

Exterior view
iThis Operator’s Manual describes all features, standard or optional, potentially available
for your vehicle at the time of purchase. Please be aware that your vehicle might not be
equipped with all features described in this manual.
FunctionPage:Trunk:Locking and unlocking76Opening and closing81Valet locking85;Rear window defroster191=Rear lamps318?Fuel filler flap220AExterior rear view mirrors95Parking position95BRoof:Power tilt/sliding sunroof192Panorama roof with power
tilt/sliding panel194
CWindshield:Wiping with washer fluid105FunctionPageCleaning264DDoors:Locking and unlocking76,
314
EWipers104Wiper blades, replacing322Wiper blades, cleaning264FHood223GFront lamps318HHeadlamp cleaning system102IFront towing eye341JTires and wheels228Rims and tires353KRear towing eye34126Exterior viewAt a glance
212_AKB; 2; 41, en-USd2ureepe,Version: 2.11.8.12009-07-17T09:14:21+02:00 - Seite 26