Page 3 of 586

TABLE OF CONTENTSIndex
10_IS250C/350C_U
2
1-1. Key informationKeys ...................................................... 24
1-2. Opening, closing and locking the doors and trunk
Smart access system with push-button start .......................... 28
Wireless remote control .............. 40
Doors.................................................... 43
Trunk..................................................... 47
1-3. Adjustable components (seats, mirrors,
steering wheel)
Front seats ........................................... 51
Driving position memory (driver’s seat) ................................. 56
Seat position memory (front passenger’s seat) ............. 60
Head restraints................................. 62
Seat belts ............................................ 65
Steering wheel.................................. 72
Anti-glare inside rear view mirror...................................... 74
Outside rear view mirrors ........... 75 1-4. Opening and closing the
windows and retractable
hardtop
Power windows................................ 78
Retractable hardtop........................ 81
1-5. Refueling Opening the fuel tank cap........... 90
1-6. Theft deterrent system Engine immobilizer system ......... 93
Alarm.................................................... 95
Theft prevention labels (U.S.A.) ............................................. 97
1-7. Safety information Correct driving posture ............... 98
SRS airbags ..................................... 100
Front passenger occupant classification system ..................... 111
Child restraint systems ................. 116
Installing child restraints ............. 120
1Before driving
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TABLE OF CONTENTSIndex
10_IS250C/350C_U
6
5-1. Essential informationEmergency flashers..................... 452
If your vehicle needs to be towed ....................................... 453
If you think something is wrong ............................................. 459
Fuel pump shut off system ....... 460
Event data recorder ..................... 461
5-2. Steps to take in an emergency If a warning light turns on or a warning buzzer
sounds... ........................................ 463
If a warning message is displayed ....................................... 472
If you have a flat tire (vehicles with standard
tires) ............................................... 486
If you have a flat tire (vehicles with run-flat
tires) ................................................ 495
If the engine will not start .......... 497
If the shift lever cannot be shifted from P........................ 499
If you lose your keys ................... 500
If the electronic key does not operate properly ................ 501
If the vehicle battery is discharged .................................. 506
If your vehicle overheats .......... 509 If the vehicle becomes stuck .... 512
If the retractable hardtop
does not close.............................. 514
6-1. Specifications Maintenance data (fuel, oil level, etc.)..................... 526
Fuel information ............................ 542
Tire information............................. 545
6-2. Customization Customizable features............... 557
6-3. Initialization Items to initialize ........................... 562
Reporting safety defects for U.S. owners........................... 564
Seat belt instructions for Canadian owners
(in French) ................................... 565
5When trouble arises
6Vehicle specifications
7For owners
Page 10 of 586
10_IS250C/350C_U
9
Tires
●Rotation
● Replacement
● Inflation pressure
● Information
P. 406
P. 486, 495
P. 536
P. 545
Tail lights P. 173
Trunk P. 47
Rear window defogger P. 238
Doors P. 43
Fuel filler door P. 90
Turn signal lights P. 156
Side marker lights P. 173
Page 19 of 586
10_IS250C/350C_U
18
Pictorial indexInstrument panel
D
Headlight cleaner switch ∗ P. 182
Trunk opener P. 47
Fuel filler door opener P. 90
Roof switch P. 81
Satellite switches P. 349
Instrument panel lightcontrol dial
P. 160
∗: If equipped
Page 20 of 586

10_IS250C/350C_U
19
For your information
Main Owner’s Manual
Please note that this manual applies to all models and explains all equipment, includ-
ing options. Therefore, you may find some explanations for equipment not installed
on your vehicle.
All specifications provided in this manual are current at the time of printing. How-
ever, because of the Lexus policy of continual product improvement, we reserve the
right to make changes at any time without notice.
Depending on specifications, the vehicle shown in the illustration may differ from
your vehicle in terms of color and equipment.
Noise from under vehicle after turning off the engine
Approximately five hours after the engine is turned off, you may hear sound coming
from under the vehicle for several minutes. This is the sound of a fuel evaporation
leakage check and, it does not indicate a malfunction.
Accessories, spare parts and modification of your Lexus
A wide variety of non-genuine spare parts and accessories for Lexus vehicles are
currently available in the market. You should know that Toyota does not warrant
these products and is not responsible for their performance, repair, or replacement,
or for any damage they may cause to, or adverse effect they may have on, your
Lexus vehicle.
This vehicle should not be modified with non-genuine Lexus products. Modification
with non-genuine Lexus products could affect its performance, safety or durability,
and may even violate governmental regulations. In addition, damage or perfor-
mance problems resulting from the modification may not be covered under war-
ranty.
Page 21 of 586

10_IS250C/350C_U
20
Installation of a mobile two-way radio system
As the installation of a mobile two-way radio system in your vehicle could affect
electronic systems such as the multiport fuel injection system/sequential multiport
fuel injection system, cruise control system, anti-lock brake system, SRS airbag sys-
tem and seat belt pretensioner system, be sure to check with your Lexus dealer for
precautionary measures or special instructions regarding installation.
Scrapping of your Lexus
The SRS airbag and seat belt pretensioner devices in your Lexus contain explosive
chemicals. If the vehicle is scrapped with the airbags and seat belt pretensioners left
as they are, this may cause an accident such as fire. Be sure to have the systems of
the SRS airbag and seat belt pretensioner removed and disposed of by a qualified
service shop or by your Lexus dealer before you scrap your vehicle.
Perchlorate Material
Special handling may apply, See www.dtsc.ca.gov/hazardouswaste/perchlorate.
Your vehicle has components that may contain perchlorate. These components may
include airbag, seat belt pretensioners, and wireless remote control batteries.
Page 24 of 586

Before driving1
23
10_IS250C/350C_U
1-1. Key informationKeys ............................................... 24
1-2. Opening, closing and locking the doors and
trunk
Smart access system with push-button start ................... 28
Wireless remote control ........ 40
Doors ............................................ 43
Trunk ............................................. 47
1-3. Adjustable components (seats, mirrors,
steering wheel)
Front seats .................................... 51
Driving position memory (driver’s seat) ........................... 56
Seat position memory (front passenger’s seat) ........ 60
Head restraints .......................... 62
Seat belts ..................................... 65
Steering wheel........................... 72
Anti-glare inside rear view mirror ............................... 74
Outside rear view mirrors ...... 75 1-4. Opening and closing the
windows and retractable
hardtop
Power windows .......................... 78
Retractable hardtop ................. 81
1-5. Refueling Opening the fuel tank cap ..... 90
1-6. Theft deterrent system Engine immobilizer system.... 93
Alarm............................................ 95
Theft prevention labels (U.S.A.)...................................... 97
1-7. Safety information Correct driving posture ......... 98
SRS airbags .............................. 100
Front passenger occupant classification system............... 111
Child restraint systems ........... 116
Installing child restraints....... 120
Page 91 of 586
90
10_IS250C/350C_U
1-5. Refueling
Opening the fuel tank cap
Perform the following steps to open the fuel tank cap.
■Before refueling the vehicle
Turn the “ENGINE START STOP” switch OFF and ensure that both
side doors and windows are closed.
■ Opening the fuel tank cap
Press the opener switch.
Turn the fuel tank cap slowly to
open.
Hang the fuel tank cap on the
back of the fuel filler door.
STEP1
STEP2
STEP3