
1
2
3
4
5
6
7
IS350/250_U
3
2-1. Driving proceduresDriving the vehicle ........................ 124
Engine (ignition) switch .............. 134
Automatic transmission.............. 139
Manual transmission .................... 145
Turn signal lever ............................ 147
Parking brake ................................. 148
Horn.................................................... 150
2-2. Instrument cluster Gauges and meters ....................... 151
Indicators and warning lights................................................. 157
Multi-information display........... 160
2-3. Operating the lights and windshield wipers
Headlight switch ............................ 165
Fog light switch .............................. 168
Windshield wipers and washer............................................. 169
Headlight cleaner switch ........... 174 2-4. Using other driving systems
Cruise control ................................ 175
Dynamic radar cruise control............................................. 179
Intuitive parking assist ................. 190
Driving assist systems.................. 196
PCS (Pre-Collision System) ........... 202
2-5. Driving information Cargo and luggage ..................... 206
Vehicle load limits........................ 209
Winter driving tips ........................ 210
Trailer towing .................................. 214
Dinghy towing (vehicles with an automatic
transmission) ................................ 215
Dinghy towing (vehicles with a manual
transmission) ................................ 216
2When driving

TABLE OF CONTENTSIndex
IS350/250_U
6
5-1. Essential informationEmergency flashers.................... 460
If your vehicle needs to be towed ........................................ 461
If you think something is wrong ......................................... 467
Fuel pump shut off system ....... 468
Event data recorder .................... 469
5-2. Steps to take in an emergency If a warning light turns on or a warning buzzer
sounds... ......................................... 471
If a warning message is displayed ...................................... 480
If you have a flat tire..................... 492
If the engine will not start ........... 501
If the shift lever cannot be shifted from P ............................. 503
If you lose your keys ................... 504
If the electronic key does not operate properly .............. 505
If the vehicle battery is discharged .................................. 509
If your vehicle overheats ............ 512
If the vehicle becomes stuck................................................. 515 6-1. Specifications
Maintenance data (fuel, oil level, etc.)...................... 518
Fuel information ............................ 534
Tire information............................. 537
6-2. Customization Customizable features............... 549
6-3. Initialization Items to initialize .......................... 555
Reporting safety defects for U.S. owners.......................... 558
Seat belt instructions for Canadian owners
(in French) ................................... 559
Abbreviation list ................................... 562
Alphabetical index .............................. 564
What to do if... ....................................... 574
5When trouble arises6Vehicle specifications
7For owners
Index

IS350/250_U
14
Pictorial indexInstrument panel
Headlight switch Turn signal lever Fog light switch P. 165
P. 147
P. 168
Shift paddle switches (automatic transmission) P. 142
Gauges and meters P. 151
Multi-information display P. 160
Windshield wiper and washer switch P. 169
Engine (ignition) switch P. 134
Trunk opener main switch P. 47
Glove box P. 333
Tilt and telescopic steering lock release lever ∗ P. 69
Tilt and telescopic steering control switch ∗ P. 70
Parking brake pedal (automatic transmission) P. 148
Audio remote control switches P. 277
Horn P. 150

IS350/250_U
17
Type B Type A
Telephone switch *2P. 302
Cruise control switch ∗
Dynamic radar cruise control switch
∗
P. 175
P. 179
Distance switch ∗
P. 179
“DISP” switch P. 161
Talk switch *2P. 302
“DISP” switch P. 161
Distance switch ∗
P. 179
Cruise control switch ∗
Dynamic radar cruise control switch
∗
P. 175
P. 179
Automatic transmission Manual transmission
VSC off
switch
∗ P. 198
ECT switch P. 140
VSC off
switch
∗ P. 198
ETCS switch P. 146
B
C
∗: If equipped
*1: Refer to “Navigation System Owner's Manual”.
*2: For vehicles with a navigation system, refer to the “Navigation System Owner’s Manual”.

IS350/250_U
20
Installation of a mobile two-way radio system
As the installation of a mobile two-way radio system in your vehicle could affect
electronic systems such as the multiport fuel injection system/sequential multiport
fuel injection system, cruise control system, anti-lock brake system, SRS airbag sys-
tem and seat belt pretensioner system, be sure to check with your Lexus dealer for
precautionary measures or special instructions regarding installation.
Scrapping of your Lexus
The SRS airbag and seat belt pretensioner devices in your Lexus contain explosive
chemicals. If the vehicle is scrapped with the airbags and seat belt pretensioners left
as they are, this may cause an accident such as fire. Be sure to have the systems of
the SRS airbag and seat belt pretensioner removed and disposed of by a qualified
service shop or by your Lexus dealer before you scrap your vehicle.
Perchlorate Material
Special handling may apply, See www.dtsc.ca.gov/hazardouswaste/perchlorate.
Your vehicle has components that may contain perchlorate. These components may
include airbag, seat belt pretensioners, and wireless remote control batteries.

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1-2. Opening, closing and locking the doors and trunk
IS350/250_U
■Operation signals
A buzzer sounds and the emergency flashers flash to indicate that the doors have
been locked/unlocked. (Locked: Once; Unlocked: Twice)
■Conditions affecting operation
The smart access system with push-button start uses weak radio waves. In the fol-
lowing situations, the communication between the electronic key and the vehicle
may be affected, preventing the smart access system with push-button start from
operating properly:
(Ways of coping: →P. 505)
●When the electronic key battery is depleted
●Near a TV tower, electric power plant, gas station, radio station, large display,
airport or other facility that generates strong radio waves or electrical noise
●When carrying a portable radio, cellular phone, cordless phone or other wire-
less communication devices
●When the electronic key is in contact with, or is covered by the following metal-
lic objects
• Cards to which aluminum foil is attached
• Cigarette boxes that have aluminum foil inside
• Metallic wallets or bags
•Coins
• Hand warmers made of metal
• Media such as CDs and DVDs
●When multiple electronic keys are in the vicinity
●When another wireless key (that emits radio waves) is being used nearby
●When carrying or using the electronic key together with the following devices
that emit radio waves
• Another vehicle's electronic key or a wireless key that emits radio waves
• Personal computer or personal digital assistant (PDA)
• Digital audio player
• Portable game system
●If window tint with a metallic content or metallic objects are attached to the rear
window

33
1-2. Opening, closing and locking the doors and trunk
1
Before driving
IS350/250_U
■Switching the door unlock function
It is possible to set which doors the entry function unlocks. Turn the “ENGINE START STOP” switch OFF.
When the indicator on the key surface is turned off, push and
hold , or for approximately 5 seconds while pushingon the key.
The setting changes each time an operation is performed, as shown below. (When
changing the setting continuously, release the buttons, wait for at least 5 seconds,
and repeat step 2.)
Unlock the doors using the electronic key and open one of the doors.
If a door is not opened within 60 seconds after is pressed, the doors
will be locked again and the alarm will automatically be set. In case that
the alarm is triggered, immediately stop the alarm. ( →P. 8 8 )
STEP1
STEP2
Multi-information
displayUnlocking doorsBeep
Hold the driver's door handle
to unlock only the driver's
door.
Exterior: Beeps three
times
Interior: Pings once
Hold the front passenger’s
door handle to unlock all
doors.
Hold either front door handle
to unlock all doors.Exterior: Beeps twice
Interior: Pings once
STEP3

36
1-2. Opening, closing and locking the doors and trunk
IS350/250_U
■Security feature
If a door is not opened within approximately 60 seconds after the vehicle is
unlocked, the anti-theft system automatically locks the vehicle again.
■Alarms and warning indicators
A combination of exterior and interior alarms as well as warnings displayed on the
multi-information display is used to prevent theft of the vehicle and unforeseeable
accidents resulting from erroneous operation. Take appropriate measures in
response to any warning indications on the multi-information display. (→P. 4 8 0 )
The following table describes circumstances and correction procedures when only
alarms are sounded.
AlarmSituationCorrection procedure
Exterior alarm
sounds once for 2
seconds
Tried to lock the doors using
the entry function while the
electronic key is still inside
the passenger compartmentRetrieve the electronic
key from the passenger
compartment and lock
the doors again.
Closed the trunk while the
electronic key is still inside
and all doors are lockedRetrieve the electronic
key from the trunk and
close the trunk lid.
Exterior alarm
sounds once for 60
seconds
Tried to exit the vehicle with
the electronic key and lock
the doors without first turning
the “ENGINE START STOP”
switch OFFTu r n t h e “ E N G I N E
START STOP” switch
OFF and lock the doors
again.
Exterior alarm
sounds once for 10
secondsTried to lock the vehicle using
the entry function while a
door is openClose all of the doors
and lock the doors
again.
Interior alarm
sounds continu-
ously
*
Tried to open the door and
exit the vehicle without shift-
ing the shift lever to P
Shift the shift lever to P.